Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/36

Click to flip

36 Cards in this Set

  • Front
  • Back
What drug is an M1 receptor antagonist?
Scopolamine
What are 5 receptors found in the CTZ?
M1: muscarinic
D2: dopamine
H1: histamine
5HT-3: Seratonin
NK1: Neurokinin
Who are the biggest culprit of N&V when it comes to drugs?
Opioids
Name different causes for N&V
Post-op N/V (most common in hospital that don't deal with chemo), obstruction, Chemo, Gastroenteritis/ gastroperesis, pregnancy, vestibular neuritis (menneers dz), unidentified origin (stress, food, ETOH)
Name the four anihistamines that can be used for N&V
Diphenhydramine (benadryl)
Dimehydrate (dramamine)
Meclizine (antivert)
Promethazine (phenergan)
What are the 3 classes of dopamine receptor antagonist?
Phenothiazines
Butyrophenone
Benzamides
What is Phenothiazines MOA?
antagonize D2 receptors in the postrema
have m1 and H1 blocking effects
Name the 2 Phenothiazines drug and their doses
Prochlorperazine (Compazine): Injectable IM/IV, 1 dose initially, then PRN
Chlorpromazine (Thorazine): same, also: used as an antipsychotic & for severe hicupps
What is Butyrophenones use for?
Preanesthetic and post-op
What are the 2 butyrophenones drugs and their info/dosages?
Droperidol (Inapsine): short 1/2 life. 1.25-5 mg IM (not rutinely used)
Haloperidol (Haldol): long life (18 hrs), mainly used as an antipsycotic
What is one Benzamides drug name/info/dosage?
Metoclopramide (Reglan): central and peripheral D3 antagoninst at low dosages, 5-HT3 blockade at higher dosage, stimulates cholinergic receptors on gastrin smooth mucles.
N/V: 5 mg one time or BID
for seratonin: up to 10 mg TID or 20 mg at one time
What are the SE of Phenothiazines?
EPS or extraparamental symtoms like dystonias, TD
ACH used for acute dystonias
Name 4 serotonin antagonist
Ondasteron (zofran)inj, desintegrated tab
Granisetron (Kytril)same
Dolasetron (Anzemet)same
palonosetron (aloxi)only for quimo induced, one time dose last 14 days
Info on Serotinin antagonists
very polpular drugs, category B, well tolerated, very costly
what are the 2 corticosteroids used for N&V
Dexamethasone (Decadron)
Methylprednisilone
which category of drug for n&v is MC used in combination with 5-HT3 & mechanism of action is not known for n&v
Corticosteroids
What are the side effects of Cannabinoids?
xerostomia (dryness around salivary glands), vertigo, hypotension
what is phase I metabolism?
oxidation, reduction, hydrolysis (elders do not have)
what is phase II of metabolism?
synthesis and oxidation
Which is the most abundant CYP-450?
CYP3A4
Where is CyP-450 located?
Primarily located in the membranes of the smooth endoplastic reticulum in the liver, small intestine and brain
In this example: CYP 3A4- what does each letter mean?
CY: cytochrome
P: P-450
3: family
A: subfamily
4: specific enzyme
what HIV drug is a very potent inhibitor used now to keep other drugs longer in the system?
Ritonavir
what is tobacco?
an IA2 inducer
what is Rifampin?
a 2C9 & 3A4 potent inducer, antimicrobial
List the 1A2 Inhibitors
Cimetidine
Quinolones
List the 2C9 inhibitors
Amiodarone
Fluconazole
Isoniazid
List the 2D6 inhibitors
Cimetidine
Clomipramine
Ritonavir
Amiodarone
Paroxetine
List the 3A4 inhibitors
Grapejuice
Amiodarone
Fluoxetine
Ketocanazole
Clarithromycin
Erythromycin
Protease Inhibitors
List the 2C19 inhibitors
Fluoxetine
Ketocanazole
Lansoprozole
List the 1A2 inducers
Tobacco
List the 2C9 inducers
Rifampin
List the 2EI inducers
Ethanol
Isoniazid
List the 3A4 inducers
Barbiturates
Carbamazipine
Rifampin
list all Cyp-450 families of inhibitors we need to know
1A2, 2C9, 2C19, 2D6, 3A4
list all the cyp-450 inducer families we need to know
1A2, 2C9, 2E1, 3A4