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46 Cards in this Set
- Front
- Back
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what are the effects of atropine poisioning
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anti cholinergic
1. red as a beet 2. Dry as a bone 3. mad as a hatter 4. blind as a bat |
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which R...
1. Increase cAMP 2. decrease cAMP 3. IP3 + DAG --> Increase Ca |
1. all beta
2. a2, M2, 3. M1, M3, a1 |
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what do my M1 R's do?
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increase IP3+ DAG to increase Ca
in the GI CNS Sympatheric Post gang for sweat |
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what do my M2 R's do?
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inhibit cAMP
in the heart some presynaptic |
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what do my M3 R's do?
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IP3 + DAG --> increase Ca
eye (pupil AND ciliary mm) lacrimal gland salivation lung GI- mobility/secretion Bladder Penis |
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where are my Nn R's
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at the ganglia
ion channels, let Na in and K out --> depolarization |
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where are my Nm R's
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at the NM junction (sk mm endplates)
Ion channel, let Na in and K out --> depolarization |
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where are my A1 R's
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IP3+ DAG --> increased Ca
post synaptic effector cells, BLOOD vessels Uterus bladder sphincters penis- shoot |
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where are my a2 R's
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inhibit cAMP
presynaptic adrenergic nerve terminals platelets lipocytes SM |
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where are my b1 R's
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increase cAMP
heart kidney- renin release lipocytes platelets SM |
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where are my b2 R's
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increase cAMP
eye- make aq humor heart some BV relax LUNGS GI Liver- glycogenolysis bladder/uterus |
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where are my b3 R's
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increase cAMP
lipocytes |
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ok so dopamine R respond to dopamine and not NE, why
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well to make NE its
TYR--> dopa --> dopamine --> NE the dopamine nerve terminal are missing dopamine hydroxylase which converts dopamine into NE |
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where are the D1/D5 R's
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increase cAMP
brain kidney |
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where are the D2 R's
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decrease cAMP
Brain SM presynaptic |
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where are the D3 R's
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decrease cAMP
brain |
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where are hte D4 R's
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brain
heart decerase cAMP |
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what are the effects the to D R's
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1/5- increase cAMP
2,3,4,- decrease cAMP |
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tell me something cool about the b2 R in the lungs
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no SNS innervation, respond to Epi in circulation, wont respond to NE
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what R does NE work on
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a1/2
b1 NO b 2 |
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where do M R CONTRACT
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usually they relax sphincters, but it contracts the esophagous
a1 will contract the sphincters |
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for the most part what R contracts your sphincters
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a1
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what do non specific b blockers do to lipids
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increase lipids bc they decrease insulin, no insulin means increased lipolysis
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what do D antagonists do to GI fx
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increase GI movement
**D1 wont work in hypovolumic shock to increase renal dilation |
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what R is in charge of gluconeogenesis and glycogenolysis
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increase blood sugars, SNS response
b2 |
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whats the predominant tone in the eye, what drug gives large effects
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PNS, a drug that takes away PNS- anticholinergic
Atropine, gives HUGE dilation |
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what is the innervation of the ciliary mm
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M3, some weak b
SNS stim wont really affect accomadation |
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where in the heart are the cholinergic R
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M2 in the ATRIA, not the vent
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what are hte R on the BV
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a1
also have M3 on endo, no innervation here though |
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what stim R release
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b1/D
a1 inhibits it |
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what are the 2 things that increase release of NE
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1. b2 receptors with A bound
2. AT1 R with ANG II bound **contrast with the whole long list of things that inhibit NE release Receptor Mediator M Ach a1 NE/Epi 5HT 5HT P1 Adenosine EP PGE H2 Histamine gamma Enkephalin D2 Dopamine P2 ATP |
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what things inhibit NE release
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Receptor Mediator
M Ach a1 NE/Epi 5HT 5HT P1 Adenosine EP PGE H2 Histamine gamma Enkephalin D2 Dopamine P2 ATP |
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what is the interplay btwn SNS and PNS at SM
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SNS releases NE to act in SM
PNS releases Ach to inhibit the SNS neuron to inhibit SNS action at the SM the SM releases PG that acts on the SNS terminal to inhibit its action |
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PG is released from ______ (SM or Exocrine Gland) to ______(inhibit or stimulate) the ______ (SNS or PNS) ganglion that acts on it
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SM
inhibit SNS **PNS also releases Ach at the SNS term that inhibits its sction |
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what is the interplay btwn SNS and PNS at exocrine glands
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PNS releases Ach to act on the gland via Ach
Ach then does feedback inhibition on its own neuron. AND also acts on endo to release NO which STIM the PNS neuron SNS releases NE on the PNS terminal to inhibit PNS action |
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what are the 3 things that will inhibit the SNS stim of SM
PRESYNAPTIC REGULATION |
1. NE released from teh SNS nerve itself. feeds back and inhibits itself
2. PG released from the SM feeds back to the SNS N and inhibits it 3. PNS stim releases presynaptic Ach to inhibit the SNS nerve |
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what are 2 things that inhibit the PNS stim of exocrine glands, what stimulates it?
**presynaptic regulation |
INHIBITED:
1. Ach from the nerver term itself. it feeds back and inhibits itself 2. NE from SNS stim presynaptically STIMULATES: 1. Ach From the PNS nerver term acts on Endo to release NO, NO stim Ach release from PNS nerve term |
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ok so in gerneral presynaptic regulation is...
postsynaptic regulation is.... |
Pre:
1. the NT from the nerve terminal itself acts to inhibit further release 2. the opposing side of ANS will inhibit 3. the tissue itself releases a substance that acts on the terminal or endo releases NO to stim glands POSTSYNAPTIC 1. R up/down regulation 2. R desensitization 3. things to alter membrane potential -IPSP- M2 - EPSP- peptides |
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what are the types of post synaptic regulation
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1. Up/down reg of R
2. Desensitixation of R 3. Altered membrane potential Inhibitory Post synaptic potential- M2 Excitatory Post Synaptic Potential- Peptides |
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how do M2 R and peptides alter transmission of signals
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post synaptic regulation of membrane potential
M2- inhibitory peptides- excitatory |
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to maintain BP the SNS acts on what 5 factors
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1. Peripheral Vascular Resistance
2. HR 3. Contractile Force 4. Venous Tone 5. Renin release **if BP decreases we increase any or all of the SNS to these things **if BP increases we decreases SNS outflow to these things |
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when BP is increased what happens to renin
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decreased release
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whenBP is decreased what does our body do
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increased SNS
1. increase peripheral vascular R a1 agonist 2. Increase HR, b1 agonist 3. increase contractile force, b1 4. increase tone, a1 5. increase renin release: D, b |
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what does renin do once D R activation stim its release
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Renin --> ANG II
**ANG II increases peripheral vascular resistance directly |
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if you increase BP with a constrictor what would the response of the body be
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decrease SNS, increase PNS
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what are IPSP and EPSP
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Inhibitory Post Synaptic potential- M2
Excitatory Post synaptic potential- Peptides , N R activation, M1 |
