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50 Cards in this Set
- Front
- Back
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Carbonic Anhydrase
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Inhibit CA in proximal tubule
decrease bicarb absorptiond decrease H+ for Na/H exchange increase Na excretion in proximal tubule increase Na/K exchange in distal tubule increase K excretion in distal tubule |
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Loop diuretics mechanisms
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Blocks Na/K/Cl cotransporter in the thick ascending loop of henle
Increased Na/K/Mg/Ca++(?)/H+ excretion |
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Thiazides mech.
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Maintains K/ATP chanels open to inhibit Na+ reabsorption in distal convoluted tubule
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K+sparing mechanism
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inhibit Na/K exchange in collecting ducts
increase Na excretion |
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Aldosterone antagonist mechanism
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competitive inhibitor of aldosterone
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Osmotic diuretics mechanism
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decrease H2O reabsopriton at the proximal tubule of the loop of henle
increase osmolarity of the TUBULAR fluid |
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ADH antagonis mech
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blocks efect of ADH
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Digitalis mechanism
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Heart: inhibits Na/K atpase
increase intracellular Na+ increase Ca+ expulsion increased intracellular Ca Increase Contractility, CO, decrease HR |
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Calcium sensitizer Mech
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increase sensitivity to Ca+ w/o ca++ increase
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PDEI mechanism
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inhibit phsophodiesterase, which breaks down cAMP
increased cAMP= increased contractility, diastolic function |
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Sympathomimetics mechanism
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B1 Agonist
Increase sympatheic activity |
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BNP mechanism
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mimics physiologic BNP
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ACE inhibitor Mechanism
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inhibit ACE which converts ANGI to ANGII
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ARB mechanism
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Block ANGII receptor
decrease preload/afterload/remodeling |
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B blocker mechanism
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decrease adrenergic (sympathetic) activity to the heart
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Vaso D mechanism
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decrease preload through VenoD
decrease afterload through ArterioD (A=A) |
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Class IA antiarrrhythmia mechanism
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Blocks open and activated Na channels
increase ERP |
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Class IB antiarrhytmia mechanism
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blocks inactivated Na channels (the slow ones that determine the length of the plateau phase (2), shortens it)
Decrease ERP |
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Class IC antiarrhythmia mechanism
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Blocks all sodium channels
no change to ERP |
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Class II antiarrhytmia mechanism
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BBlocker
decrease adrenergic activity to the heart |
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Class III antiarrhythmia mechanism
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Block K+ channels on repolarization
extend ERP |
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Class IV antiarrhythmia mechanism
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Block slow cardiac Ca++ channels
Decrease HR, contractility |
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Adenosine antiarrhytmia mechanism
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increase K+ conductance,
inhibit cAMP induced Ca+ influx |
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K+ antiarrhytmia mechanims
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Increased or deceased K+ is arrhythmogenic
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Centrally acting sympatholytics mechanism
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all have the equivalent effect of an a2 agonist
stimulate medullary a2 receptors to change BP set point |
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Adrenergic neuron blocking agent mechanism
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block release of NT
sympatholytic |
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a1 blocking agent mechanism
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block a1 w/o effect on a2
sympatholytic |
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nitrates/ites mechanism
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nitrite ion -> NO ->cGMP -> VasoD
increase coronary flow and distribution |
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Ranolazine mechanism
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inhibits pFOX- late Na current
decrease LV wall stiffness FOX RAN LATE |
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Bosentan mechanism
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endothelial receptor 1A/B antagonist
endothelins contract smm |
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Bile acid binding Resin mechanism
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binds bile acids to decresaeinterstitial absorption
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Nicotinic Acid Mechanism
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inhibits lipoprotein synthesis
inhibits LDL secretion from the liver/hepatic cholesterogenesis |
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Statin Mechanism
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Inhibit HMG CoA reductase,
decrease LDL synthesis, triglycerides increase high affinity LDL receptor, HDL cholesterol |
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Fibric Acid Derivative Mechanism
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Ligand for transcription factor PPAR-a, increase LPL activity
Increase VLDL catabolism |
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Zetia mechanism
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decreased cholesterol absorption (blocks it)
combine w/statin for synergistic effect |
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Xenical mechanism
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Blocks pancreatic lipase
decrease triglycerides breakdown in SI |
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Heparin sulfate mechanism
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HMWH
ATIII accelerant increase PTT time |
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Lepirdi anticoagulant mechanism
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Thrombin inhibitor
renal excretion |
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Enoxaparin (lovenox) mechanism
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Anticoagulant
LMWH |
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Argatroban
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direct thrombin inhibitor
liver metabolism |
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Warfarin mechanism
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Vit K analog (blocks vit K)
decrease II, VII, IX, X initially increases clotting |
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Protamine sulfate
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Anticoagulant reversal drug
Heparin antagonist (wo heparin= anticoagulation) |
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Vitamin K1
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Warfarin reversal
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Fibrinolytic agents mechanism
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all activate plasminogen
TPA and ASEs |
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Aminocaproic acid
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antifibrinolytic agent
inhibits plasminogen activation |
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Aspirin
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antiplatelet drug
decreased platelet aggregation irrev3ersible for life of platelet |
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Clopidogrel (plavix)
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Oral antiplatelet
inhibits ADP in platelets |
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Abciximab
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Antiplatelet
IV; inhibits GPIIb/IIIa |
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Eptifibatide (integrillin)
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Antiplatelet
IV; inhibits GPIIb/IIIa ratlesnake venom derived |
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Tirofaban (aggrastat)
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IV:
inhibits GPIIb/IIIa |
