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30 Cards in this Set
- Front
- Back
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For viruses, without a vaccine, there is no:
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True cure
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Viruses can be _____ genome
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DNA or RNA
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Virus: shell of protein (________) surrounding nucleic acid
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Capsid
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Influenza and HIV are ______ viruses
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RNA
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HSV and CMV are _____ viruses
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DNA
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HPV _______ is a vaccine active against 4 types of HPV
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Gardasil
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Gardasil protects against 2 types of HPV that cause _____ of cases of cervical CA and 2 types that cause genital warts
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75%
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HPV causally involved in _____ CA
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Oropharyngeal
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First step in life cycle of a DNA virus
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Attachment to membrane
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After attachment, the virus then:
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A coat forms around the virus consisting of the cell's membrane
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After coat formation, the next step in the life cycle of the DNA virus is:
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Uncoating and transfer of viral DNA to host nucleus
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Viral DNA causes _____ to viral mRNA
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Transcription
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After transcription, there is _____ by host cell ribosome
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Protein synthesis
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After protein synthesis, there is assembly of the:
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Virion
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After assembly of the vision, the is ______ and release of the newly made virus
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Budding
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Acts on the infected cells, not the virus itself
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Acyclovir
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Intracellular viral or cellular thymidine kinase adds:
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First phosphate
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Cellular kinases add two more phosphates to form:
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TTP
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TTP
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Thymidine triphosphate
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Herpes thymidine kinase will phosphorylate ____ deoxynucleoside including drugs (______ specificity)
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Any; promiscuous
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Promiscuous specificity allows _____ as only infected cells have the enzyme to phosphorylate the drug
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Selectivity
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Cellular TK does not _____ acyclovir/gangcyclovir
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Phosphorylate/activate
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Acyclovir, acycloguanosine, zovirax
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Guanine analogs
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Ganciclovir =
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Cytovene
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Activated by viral TK not by cellular TK
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Ganciclovir
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Chain terminator
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Acyclovir
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Inhibits Epstein Varr and CMV
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Acyclovir
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Acyclovir is selective:
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Virus phosphorylates drug
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Acyclovir is selective:
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Polymerase is more sensitive
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HIV is different in that it is a:
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Single stranded virus
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