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18 Cards in this Set

  • Front
  • Back
  • 3rd side (hint)
Macrolides
Mechanism of action

50S, inhibit translocation
Mechanism of resistance

Methyltransferases alter the binding site
Chloramphenical
Mechanism of action

50S, ihibit transpeptidation
Mechanism of resistance

inactivating acetyltransferases
Aminoglycosides
Mechanism of action

30s, block initiation eclicits premature termination incorp. incorrect AA
Mechanism of resistance

acetyl, phosphoryl or adenylyl conjugation
Tetracyclines
Mechanism of action

30S, prevent binding the incoming charged tRNA
Mechanism of resistance

pump out
Fluoroquinolones
Mechanism of action

inhibiting topoisomerase
Mechanism of resistance

change in sensitivity of TI "pump out"
Rifampin
Mechanism of action

inhibits DNA dependent RNA polymerase
Mechanism of resistance

Change in enzyme
Sulfonamides
Mechanism of action

Inhition of folic acid synthesis
Mechanism of resistance

decreased sensitivity of the target enzymes, increased formation of PABA, use of exogenous folate
Beta lactams
Mechanism of action

inhibition of bacterial cell wall synthesis
Mechanism of resistance

penicillinase, modification od PBP's, change of porins
Vancomycin
Mechanism of action

inhibition of peptidoglycan chain elongation
Mechanism of resistance

change in pentapeptide, D-ala-D-lactate
Mechanism of Resistance

Macrolides
Mechanism of Resistance

Methaltransferases alter binding site
Mechanism of Resistance

Chlororamphenicol
Mechanism of Resistance

inactivating acetyltransferases
Mechanism of Resistance

Aminoglycosides
Mechanism of Resistance

acetyl, phosphoryl or adenylyl conjugation
Mechanism of Resistance

tetracyclines
Mechanism of Resistance

pumped out
Mechanism of Resistance

Fluoroquinolones
Mechanism of Resistance

change in sensitivity of TI, "pump out"
Mechanism of Resistance

Rifampin
Mechanism of Resistance

change in enzyme
Mechanism of Resistance

Sulfonamides
Mechanism of Resistance

decreases sensitivity of the enzyme, increased formation of PABA, use of exogenous folate
Mechanism of Resistance

Beta lactams
Mechanism of Resistance

penicillinase, modification of PBPs, change in porins
Mechanism of Resistance

Vancomycin
Mechanism of Resistance

change in pentapeptide, D-ala-D-lactate.