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18 Cards in this Set
- Front
- Back
- 3rd side (hint)
Macrolides
|
Mechanism of action
50S, inhibit translocation |
Mechanism of resistance
Methyltransferases alter the binding site |
|
Chloramphenical
|
Mechanism of action
50S, ihibit transpeptidation |
Mechanism of resistance
inactivating acetyltransferases |
|
Aminoglycosides
|
Mechanism of action
30s, block initiation eclicits premature termination incorp. incorrect AA |
Mechanism of resistance
acetyl, phosphoryl or adenylyl conjugation |
|
Tetracyclines
|
Mechanism of action
30S, prevent binding the incoming charged tRNA |
Mechanism of resistance
pump out |
|
Fluoroquinolones
|
Mechanism of action
inhibiting topoisomerase |
Mechanism of resistance
change in sensitivity of TI "pump out" |
|
Rifampin
|
Mechanism of action
inhibits DNA dependent RNA polymerase |
Mechanism of resistance
Change in enzyme |
|
Sulfonamides
|
Mechanism of action
Inhition of folic acid synthesis |
Mechanism of resistance
decreased sensitivity of the target enzymes, increased formation of PABA, use of exogenous folate |
|
Beta lactams
|
Mechanism of action
inhibition of bacterial cell wall synthesis |
Mechanism of resistance
penicillinase, modification od PBP's, change of porins |
|
Vancomycin
|
Mechanism of action
inhibition of peptidoglycan chain elongation |
Mechanism of resistance
change in pentapeptide, D-ala-D-lactate |
|
Mechanism of Resistance
Macrolides |
Mechanism of Resistance
Methaltransferases alter binding site |
|
|
Mechanism of Resistance
Chlororamphenicol |
Mechanism of Resistance
inactivating acetyltransferases |
|
|
Mechanism of Resistance
Aminoglycosides |
Mechanism of Resistance
acetyl, phosphoryl or adenylyl conjugation |
|
|
Mechanism of Resistance
tetracyclines |
Mechanism of Resistance
pumped out |
|
|
Mechanism of Resistance
Fluoroquinolones |
Mechanism of Resistance
change in sensitivity of TI, "pump out" |
|
|
Mechanism of Resistance
Rifampin |
Mechanism of Resistance
change in enzyme |
|
|
Mechanism of Resistance
Sulfonamides |
Mechanism of Resistance
decreases sensitivity of the enzyme, increased formation of PABA, use of exogenous folate |
|
|
Mechanism of Resistance
Beta lactams |
Mechanism of Resistance
penicillinase, modification of PBPs, change in porins |
|
|
Mechanism of Resistance
Vancomycin |
Mechanism of Resistance
change in pentapeptide, D-ala-D-lactate. |
|