Pharm Exam 1

Front 1

succinylcholine

Back 1

Anectine neuromuscular blk.
non-competet.
Depolarizing
Ester Depol MEP till it doesn’t resp to ACh -> get first stim, then blockage To facilitate intubation since it’s so fast
Contraindication: History of malig. Hyperthermia
Narrow-angle glaucoma
Note: 1 in 3000 ppl. have genetic def. in pseudocholinesterase & brks. down succ very slowly;
Can trigger malignant hyperthermia

Front 2

curare / tubocurarine

Back 2

Neuromuscular blk.
Nondepol
Competitive antagonists of ACh neuromuscular blk
Attach to MEP in place of ACh; but more ACh can overcome it.
Quartinary Amine
Histamine release
diagnostic for myastinia gravis

Front 3

atracurium

Back 3

Tracrium Neuromuscular blk.
Nondepol Temporary paralysis Releases some histamine at high doses

Front 4

vecuronim

Back 4

Norcuron
Neuromuscular blk.
Nondepol
Little or no histamine release

Front 5

dantrolene

Back 5

Dantrium
Direct acting skeletal muscle relaxant Inhibits internal calcium release on muscle fibers Oral form for muscle spasms fr. chronic neuro disorder.
IV form to slow down malignant hyperthermia Major prob is liver toxicity

Front 6

baclofen

Back 6

Lioresal Centrally acting skeletal muscle relaxnt
Tmt for Spasticity Molec. Struct similar to GABA -> activate GABA-B rec, decr release of excitatory NTs like aspartate, glutamate Reduces signal transmission in spinal cord to treat spastic disorders

Front 7

diazepam

Back 7

Valium Centrally acting skeletal muscle relaxnt;
Tmt for spasticity;
benzodiazepine Incr GABA-A action (not as effective as Baclofen) Pregnant: cleft palate, respiratory depression
Accum/OD->oversedation, confusion, memory impairment Has active metabolites like Oxazepam – (Serax)

Front 8

methocarbamol

Back 8

Robaxin Centrally acting skeletal muscle relaxnt
Tmt for spasms CNS depressant -> muscle relaxant

Front 9

cyclobenzaprine

Back 9

Flexeril Centrally acting skeletal muscle relaxnt
Tmt for spasms;
w/ antichol actn Structural reln to tricyclic antidepressants Not effective in tmt for muscle spasms fr. CNS pathology

Front 10

orpenadrine

Back 10

Norflex Centrally acting skeletal muscle relaxnt
Tmt for spasms;
w/ antichol actn
Good oral absorption