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16 Cards in this Set
- Front
- Back
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Lispro
Aspart Regular |
Short-acting insulin
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NPH
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intermediate insulin
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Glargine
Detemir |
Long-acting insulin
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Sulfonylureas
1st: tolbutamide, chlorpropamide 2nd: glyburide, glimepiride, glipizide |
close K+ channel in beta cell membrane--> cell depolarizes, calcium influx, triggers insulin release
tox: 1st is disulfiram-like. 2nd is hypoglycemia |
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Metformin
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insulin sensitizer. can be used in pts without islet fx
tox: lactic acidosis |
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Glitazones (Pioglitazone, rosiglitazone)
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increases target cell response to insulin.
use: type 2 DM either mono or combined therapy tox: weight gain, edema. hepatotoxicity, CV toxicity |
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alpha-glucosidase inhibitors (acarbose, miglitol)
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inhibits intestinal brush border alpha-glucosidases (delayed sugar hydrolysis and glc abs.)
tox: GI disturbance |
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Pramlintide
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decreases glucagon
tox: hypoglycemia, nausea, diarrhea |
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Exanetide (GLP-1 mimetic)
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increase insulin, decrease glucagon release
tox: n/v, ?pancreatitis |
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Orlistat
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inhibits pancreatic lipases
use: long-term obesity mgmt tox: steatorrhea, GI discomfort, reduced fat-soluble vit. abs., HA |
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Sibutramine
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5-HT, NE reuptake inhibitor.
use: short/long-term obesity mgmt tox: HTN, tachy |
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PTU, methimazole
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inhibit organification/coupling of thyroid hormone.
PTU ONLY decreases T4-->T3 conversion tox: rash, agranulocytosis, aplastic anemia |
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Levothyroxine, triidothyronine
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thyroxine replacement
tox: tachy, heat intolerance, tremors, arrhythmias |
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Glucocorticoids (triamcinolone)
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inhibits phospholipase A2 and COX-2 expression
tox: Cushing's syndrome |
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demeclocycline
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poisons collecting tubule so there is no response to ADH (ADH antagonist).
tetracycline family. use: SIADH Tox: photosensitivity, abnl bone/teeth, nephrogenic DI |
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Octreotide
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somatostatin analogue, but increased duration of action.
inhibits release of: GH, insulin, glucagon, gastrin, secretin, CCK, VIP |
