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90 Cards in this Set

  • Front
  • Back
human recombinant GH
somatropin, somatrem
GH uses 3
GH def, turner's, burn victims
IGF analogues
mecasermin
GHRH
sermorelin
synthetic SMST
ocreotide
tox of ocreotide 3
N, cramps, gallstones
Tx for acrogmegaly 3
ocreotide, bromocriptine, pegvisomant
GH-R antagonist
pegvisomant
Tx prolactinoma 2
bromocriptine, pergolide
menotropin is
partially degraded FSH, LH
urofollitropin is
mostly FSH
Infertile women Tx
menotropi/urofollitropin for follicular maturation; hCG for ovulation
chorionic gonadotropin given for
infertile men, women
if chorionic gonadotropin descends testicle, then
perm descent probably occur at puberty
gonadorelin is
GnRH
leuprolide is
GnRH-R agonist
ganirelix is
GnRH-R antagonist
ganirelix is used for
suppress premature LH surge
leuprolide is used for4
prostate CA, PCOS, uterine fibroids, endometriosis
pitocin used for 2
induce labor; milk letdown
Tx to inh premature labor
ritodrine, terbutaline (beta-2 agonist)
which V receptor mediates vasoconstriction
V1
which V receptor mediates ADH axn
V2
desmopressin used for
central DI
tox of desmopressin
facial pallor, urticaria
demeclocycline M/A
inh action of ADH
ADH-R antagonist
conivaptan
synthetic ACTH
cosyntropin
short acting coticoids 2
hydrocortisone, cortisone
intermediate-acting corticoids
prednisone, prednisolone, methylprednisolone, triamcinolone
long-acting corticoids
dexamethasone, betamethasone
mineralocorticoid
fludrocortisone
aerosol corticoid
beclomethasone, flunisolide
which glucocorticoids have the strongest anti-infl fx
longer acting
tox of corticoids 7
Cushing, peptic ulcer, psychosis, catarcts, glaucoma, inf susceptibility, growth suppression
insulin M/A
binds alpha chains -> beta chains autophosphorylate -> IRS
short-acting insulin preps 4
insulin glulisine, lispro insulin, insulin aspart, cyrstalline zinc
intermediate insulin prep 2
NPH, lente insulin
long-acting insulin preps 2
insulin glargine, insulin determir
pre-mixtures 2
NPH/Lispro, NPH/Aspart
factors that inc need for insulin 5
hyperthyroidism, stress, stop physical exercise, inc food uptake, Rx
sulfonylureas M/A
bind R near K channel -> dec K efflux -> depolarization -> inc Ca influx -> insulin secretion
Tox sulfonylurea 2
hypoglycemia, disulfiram-like rxn (1st gen)
sulfonylureas 6
tolbutamide, tolazamide, chlorpropamide, glyburide, glipizide, glimepiride
metformin M/A
dec gluconeogenesis, inc glucose uptake
Rx that req insulin production (T2DM)
metformin, sulfonylurea
metformin tox 4
metallic taste, GI upset, anorexia, rare lactic acidosis
DM drug that does not produce hypoglycemia
metformin
acarbose & miglitol M/A
delay absorption of glucose, monosacchardies
acarbose tox 4
flatulence, cramps, diarrhea, may dec Fe absorption
pioglitazone/rosiglitazzone M/A
bind PPAR-g-R -> inc insulin-response gene transcription -> dec insulin resistance
pioglitazone tox 4
wt gain, edema, inc risk HF & Fx
repaglinide/nateglinide M/A
close K channel -> stim insulin secretion
difference b/t sulfonylurea & repaglinide
repaglinide are short acting
sitagliptan/saxagliptan M/A
inh dipeptidyl-peptidase 4-> inc insulin synth & release, dec glucagon production
exenatide M/A 3
stim insulin secretion when hyperglycemic, slow gastric emptying, block glucagon release
parmlintide M/A 2
dec glucogon secretion, modulate postprandial glucose level
injectable hypoglycemics 2
exenatide, pramlintide
oral hypoglycemics 6
sitagliptan, repaglinide, pioglitazone, acarbose, metformin, sulfonylurea
route of insulin preps
subcutaneous to abdomen/buttocks/extermity; pump or pen
most common estrogens used for OCP 2
ethinyl estradiol, mestranol
progesterones used ofr OCP 4
norethindrone, norgestrel, etonogestrel, medroxyprogesterone
M/A small does progestins
change cervical mucus & endometrium so unfavorable for implantation
levonorgestrel used for
postcoital emergency
estrogen tox 5
nausea, breast tenderness, hyperpigmentation, VTE, hyperglycemia, HTN
CA that has inc risk w/ estrogens but not w/ estrogen/progesterone combo
endometrial CA
estrogen inc risk of which CA 2
breast, ovarian
progesterone tox 2
uterine bleeding, HTN sometimes, older can have adrogenic fx
natural steroid estrogens 2
estradiol, conjuigated estrogens
synthetic steroid estrogens 2
ethinyl estradiol, mestranol
injected progesterones 3
progesterone, hydroxyprogesterone, medroxyprogesterone
oral progesterones 2
medroxyprogesterone, megestrol
tamoxifen M/A
competitive estrogen-R blocker in breast tissue
clomiphene M/A
partial estrogen-R agonist -> dec feedback inh -> inc GnRH
raloxifene M/A
estogen-R anatgonist in breast, partial bone/chol metabolism agonist
tamoxifen use
breast CA
raloxifene use
osteoperosis in postmenopausal
fulvestrant M/A
down-regulates estrogen R
fulvestrant use
postmenopausal women mets breast CA
exemestane M/A
aromatase inh
exemestane use
advanced breast CA postmenopausal
mifepristone M/A
progesterone-R antagonist
mifepristone use
terminate pregnancy
androgenic and anabolic 2
methyl/testosterone
anabolic > androgenic 3
fluoxymesterone, nandrolone, oxandrolone
flutamide M/A
competitive androgen-R antagonist
finasteride M/A
inh 5-alpha reductase
ketoconazole antiandrogen use
inh gonadal steroid synth
flutamide use v. finasteride
flutamide for prostate CA; finasteride for BPH
cyproterone M/A
progestogenic anti-androgen