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90 Cards in this Set
- Front
- Back
human recombinant GH
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somatropin, somatrem
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GH uses 3
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GH def, turner's, burn victims
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IGF analogues
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mecasermin
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GHRH
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sermorelin
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synthetic SMST
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ocreotide
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tox of ocreotide 3
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N, cramps, gallstones
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Tx for acrogmegaly 3
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ocreotide, bromocriptine, pegvisomant
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GH-R antagonist
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pegvisomant
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Tx prolactinoma 2
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bromocriptine, pergolide
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menotropin is
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partially degraded FSH, LH
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urofollitropin is
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mostly FSH
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Infertile women Tx
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menotropi/urofollitropin for follicular maturation; hCG for ovulation
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chorionic gonadotropin given for
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infertile men, women
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if chorionic gonadotropin descends testicle, then
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perm descent probably occur at puberty
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gonadorelin is
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GnRH
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leuprolide is
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GnRH-R agonist
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ganirelix is
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GnRH-R antagonist
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ganirelix is used for
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suppress premature LH surge
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leuprolide is used for4
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prostate CA, PCOS, uterine fibroids, endometriosis
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pitocin used for 2
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induce labor; milk letdown
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Tx to inh premature labor
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ritodrine, terbutaline (beta-2 agonist)
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which V receptor mediates vasoconstriction
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V1
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which V receptor mediates ADH axn
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V2
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desmopressin used for
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central DI
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tox of desmopressin
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facial pallor, urticaria
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demeclocycline M/A
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inh action of ADH
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ADH-R antagonist
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conivaptan
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synthetic ACTH
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cosyntropin
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short acting coticoids 2
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hydrocortisone, cortisone
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intermediate-acting corticoids
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prednisone, prednisolone, methylprednisolone, triamcinolone
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long-acting corticoids
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dexamethasone, betamethasone
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mineralocorticoid
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fludrocortisone
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aerosol corticoid
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beclomethasone, flunisolide
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which glucocorticoids have the strongest anti-infl fx
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longer acting
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tox of corticoids 7
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Cushing, peptic ulcer, psychosis, catarcts, glaucoma, inf susceptibility, growth suppression
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insulin M/A
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binds alpha chains -> beta chains autophosphorylate -> IRS
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short-acting insulin preps 4
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insulin glulisine, lispro insulin, insulin aspart, cyrstalline zinc
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intermediate insulin prep 2
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NPH, lente insulin
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long-acting insulin preps 2
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insulin glargine, insulin determir
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pre-mixtures 2
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NPH/Lispro, NPH/Aspart
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factors that inc need for insulin 5
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hyperthyroidism, stress, stop physical exercise, inc food uptake, Rx
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sulfonylureas M/A
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bind R near K channel -> dec K efflux -> depolarization -> inc Ca influx -> insulin secretion
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Tox sulfonylurea 2
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hypoglycemia, disulfiram-like rxn (1st gen)
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sulfonylureas 6
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tolbutamide, tolazamide, chlorpropamide, glyburide, glipizide, glimepiride
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metformin M/A
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dec gluconeogenesis, inc glucose uptake
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Rx that req insulin production (T2DM)
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metformin, sulfonylurea
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metformin tox 4
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metallic taste, GI upset, anorexia, rare lactic acidosis
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DM drug that does not produce hypoglycemia
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metformin
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acarbose & miglitol M/A
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delay absorption of glucose, monosacchardies
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acarbose tox 4
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flatulence, cramps, diarrhea, may dec Fe absorption
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pioglitazone/rosiglitazzone M/A
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bind PPAR-g-R -> inc insulin-response gene transcription -> dec insulin resistance
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pioglitazone tox 4
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wt gain, edema, inc risk HF & Fx
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repaglinide/nateglinide M/A
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close K channel -> stim insulin secretion
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difference b/t sulfonylurea & repaglinide
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repaglinide are short acting
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sitagliptan/saxagliptan M/A
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inh dipeptidyl-peptidase 4-> inc insulin synth & release, dec glucagon production
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exenatide M/A 3
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stim insulin secretion when hyperglycemic, slow gastric emptying, block glucagon release
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parmlintide M/A 2
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dec glucogon secretion, modulate postprandial glucose level
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injectable hypoglycemics 2
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exenatide, pramlintide
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oral hypoglycemics 6
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sitagliptan, repaglinide, pioglitazone, acarbose, metformin, sulfonylurea
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route of insulin preps
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subcutaneous to abdomen/buttocks/extermity; pump or pen
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most common estrogens used for OCP 2
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ethinyl estradiol, mestranol
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progesterones used ofr OCP 4
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norethindrone, norgestrel, etonogestrel, medroxyprogesterone
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M/A small does progestins
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change cervical mucus & endometrium so unfavorable for implantation
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levonorgestrel used for
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postcoital emergency
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estrogen tox 5
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nausea, breast tenderness, hyperpigmentation, VTE, hyperglycemia, HTN
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CA that has inc risk w/ estrogens but not w/ estrogen/progesterone combo
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endometrial CA
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estrogen inc risk of which CA 2
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breast, ovarian
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progesterone tox 2
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uterine bleeding, HTN sometimes, older can have adrogenic fx
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natural steroid estrogens 2
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estradiol, conjuigated estrogens
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synthetic steroid estrogens 2
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ethinyl estradiol, mestranol
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injected progesterones 3
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progesterone, hydroxyprogesterone, medroxyprogesterone
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oral progesterones 2
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medroxyprogesterone, megestrol
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tamoxifen M/A
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competitive estrogen-R blocker in breast tissue
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clomiphene M/A
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partial estrogen-R agonist -> dec feedback inh -> inc GnRH
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raloxifene M/A
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estogen-R anatgonist in breast, partial bone/chol metabolism agonist
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tamoxifen use
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breast CA
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raloxifene use
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osteoperosis in postmenopausal
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fulvestrant M/A
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down-regulates estrogen R
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fulvestrant use
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postmenopausal women mets breast CA
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exemestane M/A
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aromatase inh
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exemestane use
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advanced breast CA postmenopausal
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mifepristone M/A
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progesterone-R antagonist
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mifepristone use
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terminate pregnancy
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androgenic and anabolic 2
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methyl/testosterone
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anabolic > androgenic 3
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fluoxymesterone, nandrolone, oxandrolone
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flutamide M/A
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competitive androgen-R antagonist
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finasteride M/A
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inh 5-alpha reductase
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ketoconazole antiandrogen use
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inh gonadal steroid synth
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flutamide use v. finasteride
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flutamide for prostate CA; finasteride for BPH
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cyproterone M/A
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progestogenic anti-androgen
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