Pharm Dr. Krugger Sympathomimetics

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Pneumonic for beta receptors

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You have 1 heart (Beta 1) and 2 lungs (Beta 2)

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This is the drug of choice for anaphylactic shock

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Epinephrine

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Phenylisopropylamines that are used legitimately and abused for narcolepsy, attention deficit disorder, and weight reduction

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Amphetamines

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Alpha agonist used to produce mydriasis and reduce conjunctival itching and congestion caused by irritation or allergy, it does not cause cycloplegia

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Phenylephrine

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Newer alpha 2 agonist (apraclonidine and brimonidine) treat glaucoma by acting to

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Reduce aqueous secretion

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Short acting Beta 2 agonists that is drug of choice in treatment of acute asthma but not recommended for prophylaxis

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Albuterol

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Longer acting Beta 2 agonist is recommended for prophylaxis of asthma

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Salmeterol

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These agents increase cardiac output and may be beneficial in treatment of acute heart failure and some types of shock

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Beta1 agonists

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These agents decrease blood flow or increase blood pressure, are local decongestants, and used in therapy of spinal shock (temporary maintenance of blood pressure which may help maintain perfusion

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Alpha1 agonists

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Shock due to septicemia or myocardial infarction is made worse by

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Increasing afterload and tissue perfusion declines

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Epinephrine is often mixed with a local anesthetic to

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Reduce the loss from area of injection

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Chronic orthostatic hypotension can be treated with

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Midodrine

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Beta 2 agonist used to suppress premature labor, but cardiac stimulatory effects may be hazardous to mother and fetus

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Terbutaline

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Sympathetic agent which stimulates heart rate and can dilate vessels in skeletal muscle at low doses

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Epinephrine

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Mast cells to reduce release of histamine and inflammatory mediators

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Epinephrine

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Agent used in shock because it dilates coronary arteries and increases renal blood flow

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Dopamine

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Agent which stimulates cardiac contractile force more than rate with little effect on total peripheral resistance

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Dobutamine

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Long acting sympathomimetic, sometimes used to improve urinary continence in children and elderly with enuresis

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Ephedrine

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Alpha 1 agonist toxicity

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Hypertension

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Beta 1 agonist toxicity

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Sinus tachycardia and serious arrhythmias

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Beta 2 agonist toxicity

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Skeletal muscle tremor, tachycardia

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The selective agents loose their selectivity at

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high doses