Pharm Dr. Krugger Drugs Used In Coagulation Disorders

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Vitamin K dependent anticoagulant

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Warfarin (PT)

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Warfarin is contraindicated in

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Pregnancy

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Anticoagulant of choice in pregnancy

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Heparin

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Heparin (PTT) increases activity of

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Antithrombin 3

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Route of administration of warfarin

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Oral

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Routes of administration of heparin

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IV and IM (only LMW)

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SE of both warfarin and heparin

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Bleeding

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SE of heparin

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Heparin induced thrombocytopenia (HIT)

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Alternative anticoagulant used if HIT develops

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Lepirudin

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Antidote to reverse actions of warfarin

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Vitamin K or fresh frozen plasma

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Antidote to reverse actions of heparin

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Protamine sulfate

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MOA of aspirin

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Irreversibly blocking cyclooxygenase

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Agent used to treat MI and to reduce incidence of subsequent MI

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Aspirin, metoprolol

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SE of Aspirin

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GI bleeding

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Antiplatelet drug reserved for patients allergic to aspirin

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Ticlopidine

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SE for ticlopidine

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Neutropenia and agranulocytosis

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Effective in preventing TIA's

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Clopidogrel and ticlopidine

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Prevents thrombosis in patients with artificial heart valve

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Dipyridamole

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Block glycoprotein IIb/IIIa involved in platelet cross-linking

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Abciximab, tirofiban and eptifibatide

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MOA of thrombolytics

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Degradation of fibrin clots and are administered IV

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Thrombolytics are used for

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Pulmonary embolism and DVT

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Thrombolytic that can cause allergic reaction

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Streptokinase

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Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA

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Tissue plasmin activator

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SE of tPA

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Cerebral hemorrhage

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Antidote for thrombolytics

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Aminocaproic acid