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16 Cards in this Set
- Front
- Back
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Drugs decrease intestinal absorption of cholesterol
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Bile acid-binding resins
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Cholestyramine and colestipol are
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Bile acid-binding resins
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Major nutritional side effect of bile acid-binding resins
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Impair absorption of fat soluble vitamin absorption (A,D,E,K)
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MOA of lovastatin (STATIN)
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inhibits HMG COA reductase
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HMG CoA reductase inhibitors are contraindicated in
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Pregnancy
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MOA of drug or foods (grapefruit juice) that increase statin effect
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Inhibit Cytochrome P450 3A4
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SE of HMG COA reductase inhibitors
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Rhabdomyolysis and Hepatotoxicity
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Monitoring parameter to obtain before initiation of STATINS
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LFT's
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Decreases liver triglycerol synthesis
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Niacin
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SE of niacin
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Cutaneous flush
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Cutaneous flush and be reduced by pretreatment with
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Aspirin
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Fibrates (gemfibrozil) increase activity of
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Lipoprotein lipase
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Most common SE of fibrates
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Nausea
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Fibrates are contraindicated in
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Pregnancy
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Concurrent use of fibrates and statins increases risk of
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Rhabdomyolysis
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New class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins
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Ezetimibe (Zetia)
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