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8 Cards in this Set

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metformin
acts on liver and muscle to increase peripheral action of insulin, decrease gluconeo in liver, increase GLUT4 in muscle, use for obese
sulfonylureas
ATP ABC binding cassette, decrease K conductance, increase insulin secretion, first generation is renal excrete, second generation is fecal excrete, both hepatic
repaglinide
similar to sulfonylurea, postprandial hyperglycemia, decrease K conductance, rapid and brief
nateglinide
pheylalanine derivative, postprandial hyperglycemia, decrease K conductance, rapid and shorter than repaglinide so risk of hypoglycemia least
diazoxide
increase k channel conductance, for insulinoma
glucagon
reverse BB overdose, relax GI for xray, insulin overdose, diagnose pheo
thiazolidinediones, pioglitazone, rosiglitazone
ligand for PPARgamma (adipose) and RXR; use in obese, increase GLUT4 and 1, decrease TNFalpha, leptin, increase lipoprotein lipase, troglitazone has hepatocellular injury
None
a glucosidase inhibitors
acarbose, miglitol… for fasting and postprandial hyperglycemia, effective no matter age weight etc.