Pharm Cv

Front 1

A slective a1A blocker used in BPH

Back 1

Tamulosin, selective a1A blocker used in ProstAte, -zosin (a1A & a1B blockers) used in BPH & HTN

Front 2

ACE/ARB ADR

Back 2

Miscarriage, hyperkalemia, nephrotoxic [& cough with ACEs]

Front 3

ACE/ARB indications

Back 3

HTN, CHF/Post-MI, Diabetic Nephropathy

Front 4

Adrenergic blocker used in Pheo & rarely BPH

Back 4

Phenoxybenzamine, irreversible a1 & a2 antagonist, used in Pheo & rarely BPH (better agent)

Front 5

Antihypertensives a/w 1st dose syncope

Back 5

Prazosin (a1-antagonists) are a/w 1st dose syncope (usually give 50% dose 1st time)

Front 6

CCB preference for heart muscle

Back 6

CCB heart preference: verapamil > diltiazem > nifedipine

Front 7

CCB preference for smooth muscle

Back 7

CCB smooth muscle preference: nifedipine > diltiazem > verpamil

Front 8

CHF Tx

Back 8

Dig, ACE/ARB, BB (DOC Carvedilol, 2nd: Metoprolol Succinate or Bisoprolol), Na+ reduction, Diuretics

Front 9

DOC for intermittent claudication

Back 9

Cilostazol, a PDE3 inhibitor, is DOC for intermittent claudication. Incr cAMP -> Vasodilation

Front 10

DOC for ventricular arrhythmias post-MI

Back 10

Lidocaine (class 1B) works only on ischemic tissue, DOC for ventricular arrhythmias post-MI

Front 11

Decrease AP duration by shortening repolarization phase

Back 11

Class 1B Anti-arrhythmics: Lidocaine/Mexiletine/Tocainide/Phenytoin (ventr arrhythmias, esp digitioxin-induced arrhythmias)

Front 12

Digoxin MOA

Back 12

Inhibits Na/K ATPase -> Decr Na/Ca exchanger -> Incr [Ca]

Front 13

Digoxins MOA & Indication

Back 13

Digoxins reversibly inhibit Na/KA ATPase, used in CHF & Atrial flutter/fib

Front 14

Diuretic to use in Pulm Edema with sulfa allergy

Back 14

Ethacrynic acid is nonsulfa loop diuretic. Thiazides & CAIs are sulfa drug.

Front 15

Dopamine order of receptor preference

Back 15

Dopamine: D1=D2 > beta > alpha

Front 16

Ephedrine MOA & Indications

Back 16

Releases catecholamiine (more alpha), used in Hypotension & asthma [same MOA as amphetamine, but less BBB penetration]

Front 17

Gemfibrozil MOA

Back 17

Fibrates work on PPARa

Front 18

HTN med that blocks storage & release of catecholamines & serotonin from neurons

Back 18

Reserprine blocks VMAT, which transports catecholamines & 5HT into vesicles, may cause depression

Front 19

Heparin MOA

Back 19

Decr AT3 -> Decr Factors 2 & 9-12 [IV only]

Front 20

List anti-platelet drugs that block GP 2b/3a

Back 20

Abciximab, EptiFIBAtide, TiroFIBAn

Front 21

List the nonselective alpha blockers

Back 21

Phenoxybenzamine (irrev) & Phentolamine (revers), both used in Pheo

Front 22

Loop diuretics MOA

Back 22

Loop diuretics inhibit Na/K/2Cl Symporter in thick loop [increase urinary excretion of all ions except HCO3-]

Front 23

Propranolol MOA & S/E

Back 23

Propranolol is nonselective Beta-blocker, may cause bronchospasm (CI in asthma & COPD)

Front 24

Reserprine MOA & S/E

Back 24

Reserprine blocks VMAT, which transports catecholamines & 5HT into vesicles, may cause depression

Front 25

Spironolactone S/E

Back 25

Spironolactone causes gynecomastia, agranulocytosis, nephrotoxic, hepatotoxic, tumors

Front 26

Streptokinase MOA

Back 26

Streptokinase activates plasminogen into plasmin

Front 27

Thiazide diuretics MOA

Back 27

Thiazides inhibit Na/Cl symporter in early DCT

Front 28

What CV drug causes blurry yellow vision?

Back 28

Digoxin causes xanthopsia, blurry yellowed vision

Front 29

What reverses Heparin?

Back 29

Heparin is reversed by Protamine Sulfate

Front 30

Which BBs are approved for CHF?

Back 30

Carvedilol (best) & Metoprolol Succinate (not as good) [maybe Bisoprolol (bi-SOUP-rolol), but not approved]

Front 31

Which CCB is a Phenylalkylamine?

Back 31

Verapamil is the only Phenylalkylamine CCB approved in the US

Front 32

Which anticogulant is contraindicated in pregnancy?

Back 32

Warfarin is CI in preg (X), crosses placenta, may cause abortion or fetal bleeding

Front 33

Which hyperlipidemics cause hepatotoxicity?

Back 33

Niacin & statins -> hepatotoxic

Front 34

Zygris MOA & Indication

Back 34

Activated Protein C, used as last resort in Septic Shock

Front 35

Anaphylactic Shock Tx

Back 35

Benadryl, Aminophylline, Steroids, Epinephrine (BASE)

Front 36

Heparin MOA

Back 36

Heparin is Antithrombin III inhibitor, IV only, used in clotting emergencies & as DVT prophylaxis

Front 37

Heparin MOA

Back 37

Decr AT3 -> Decr Factors 2 & 9-12

Front 38

List anti-platelet drugs that block GP 2b/3a

Back 38

Abciximab, EptiFIBAtide, TiroFIBAn

Front 39

What reverses Heparin?

Back 39

Heparin is reversed by Protamine Sulfate

Front 40

Which anticogulant is contraindicated in pregnancy?

Back 40

Warfarin is CI in preg (X), crosses placenta, may cause abortion or fetal bleeding

Front 41

Minoxidil MOA

Back 41

K channel activator

Front 42

Gemfibrozil MOA

Back 42

Fibrates work on PPAR

Front 43

List anti-thrombolytics

Back 43

Streptokinase/Urokinase, altepase (t-PA), retapalase, tenectaplase

Front 44

Which anti-thrombolytic is considered the most active?

Back 44

Tenectaplase has faster thrombolytic properties

Front 45

Another name for Tissue Plasminogen Activator

Back 45

Altepase

Front 46

Stem for plasminogen activators

Back 46

-tepase (except Streptokinase/Urokinase)

Front 47

Labetalol MOA

Back 47

Nonselective alpha&beta blocker 1:3 ratio

Front 48

Labetalol CIs

Back 48

Asthma, heart block, & bradycardia [nonselective alpha/BETA BLOCKER]

Front 49

A-fib Tx with no serious heart dz

Back 49

Flecainide, Propafenone, Sotalol

Front 50

A-fib Tx with concurrent heart dz

Back 50

Amiodarone or Dofetilide

Front 51

Serotonin Syndrome Tx

Back 51

IVF, Cryptoheptadine, Benzos