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6 Cards in this Set

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What is D-penicillamine used for? What are the severe ADRs?
Used to chelate heavy metals, and used to treat heavy metal poisoning. Severe ADRs are dermatitis to nephritis to aplastic anemia.
What monoclonal antibody is fully human? That is used to treat Rheumatoid Arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease. It reduces TNF in the body.
Adalimumab


Ankur you might be down...tired...but don't give up keep pushing you got this! 600 show them!
What happens if you have a HGPRT deficiency?
Results in an accumulation of Hypoxanthine and Guanine. This excess is metabolized by xanthine oxidase to uric acid. This can be prevented with Allopurinol.
MOA of cancer resulting in gout?
Because of overabundance of nucleic acid from dying malignant cells.
At low doses probenecid does what?
Low doses it competes with uric acid at the renal transporter causing increased uric acid levels.
At high doses probenecid does what?
High doses it acts to inhibit reabsorption of uric acid.