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16 Cards in this Set

  • Front
  • Back
Selective Nicotinic Receptor Antagonists
Tubocurarine
Trimethaphan
Tubocurarine - Actions?
Blocks ACh at Skeletal Muscle
Trimethaphan
Block ACh at Autonomic Ganglia
Direct acting ACh Agonists
Alkaloids
Pilocarpine
Muscarine
Direct acting ACh Agonists
Esters
Carbachol
Bethanechol
Indirect Acting ACh Antagonists -Reversible
Alkaloids
Physostigmine
Indirect Acting ACh Agonists-Reversible
Carbamates
Neostigmine
Pyridostigmine
Edrophonium
Treatment of Myasthenia Gravis
Neostigmine
Pyridostigmine
Ambenonium
Diagnostic use of Edrophonium
Small dose given to differentiate b/w Cholnergic Crisis and Myasthenic Crisis.
Improvement upon admin. = low dose of cholinesterase inhibitor (increase dose)
No improvement = depol. block (reduce dose)
Pilocarpine - Uses?
Glaucoma
Xerostomia (after radiation/Sjogrens)
Low dose = paradoxical HTN
Bethanechol - Uses?
P.O. paralytic ileus
P.O. urinary retention
Subcutaneous admn.
Neostigmine - Uses?
Myasthenia gravis
P.O. Paralytic ileus
P.O. Urinary retention
Physostigmine - Uses?
Glaucoma
Atropine Poisoning
Edrophonium - Uses?
Short acting (8-10min)
Mysthenic crisis v. cholinergic crisis diagnosis
Alzheimer's Disease Drugs
CNS acting AChE Inhibitors:
Tacrine
Donepezil
Rivastigmine
Galantamine
Botulinum Toxin - Actions and Uses?
Degrade synaptobrevin - prevents synaptic vesicle from fusion with axon membrane.
Achlasia
Strabismus
Blepharospasm
Facial lines and wrinkles