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23 Cards in this Set

  • Front
  • Back
tetracycline mechanism of action
bind 30S ribosomal subunit- bacteriostatic
tetracycline drug with broadest spectrum and less common resistance
tigecycline
side effect includes deposition in developing bones and teeth
tetracyclines
macrolide mechanism of action
bind 50S ribosomal subunit- bacteriostatic
macrolide with least resistance
telithromycin
macrolide that does not inhibit CYP450
azithromycin
cardiac side effect of macrolide antibiotics
QT prolongation
clindamycin class
lincosamide
clarithromycin class
macrolide
mechanism of action for clindamycin
bind to 50S ribosomal subunit- bacteriostatic
quinupristin-dalfopristin class
streptogramin
mechanism of action for streptogramins
bind to 50S ribosomal subunit- bactericidal
associated with grey baby syndrome
chloramphenicol
mechanism of action for chloramphenicol
bind to 50S ribosomal subunit- bacteriostatic
linezolid class
oxazolidinone
linezolid mechanism of action
binds to 23S RNA of 50S subunit- bacteriostatic
antibiotic that can cause serotonin syndrome when combined with an SSRI
linezolid
why do tetracyclines have little effect on mammalian protein synthesis?
an active efflux mechanism prevents intracellular accumulation
used as a backup drug for salmonella and for treatment of pneumococcal/meningococcal meningitis in beta-lactam sensitive patients
chloramphenicol
occurs as a consequence of using outdated tetracyclines
Fanconi's Syndrome (form of renal tubular necrosis)
macrolide that allows levels to be higher in tissues and phagocytes rather than plasma
azithromycin
main use of clindamycin
severe infections caused by anaerobes such as bacteroides
hematologic adverse effects of linezolid
thrombocytopenia and neutropenia