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11 Cards in this Set
- Front
- Back
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gold
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suppresses macrophages and other phagocytes by depressing their lysosomal activity. it accumulates in synovial fluid and body wide macrophages-->slows the progression of bone and articular destruction.
most effective agent for rapidly progressive RA, but is not used for acute attacks contrain: in hepatic or kidney dis, pregnencey SE: dermatitis of skin and mucus memb, nephritis, proteinuria, agranulocytosis, chrysiasi (grey blue discoloration of skin), aplastic anemia OD treated wiht dimercaprol. gold agents: auranofin, gold sodium thiomalate |
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D-penicillamine
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reduces rheumatoid factor but not used due to toxicity
chelate heave metall so used to treat heavy metal poisoning |
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Methotrexate
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folic acid antaonist
inhibits dihydrofolate reductase lower doses treat RA DE: cytopenia, leukopenia, megaloblastic anemia, MUCOSAL ULCERATION, NAUSEA, liver cirrhosis and acute pneumonia like syndrome (rare) |
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thalidomide
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inhibits production and secretion on TNF
treat: leprosy, HIV associated skin lesions, multiple myeloma very teratogenic: women must have - prego test and start OCP before taking thalidomide |
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pentoxyfilline
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phosphodiesterase inhibitor-->TNF secretion inhibition
also platelet aggregation inhibitor treate: acute alcoholic hepatitis |
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infliximab
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monoclonal AB directed against TNF
IV form treate: RA, ankylosing spondylitis, psoriatic arthritis, moderate to sever ulcerative colitis, crohn's dis increase the risk of spesis, TUBERCULOSIS, lymphoma and other cancers, multiple sclerosis, myelitis, optic neuritis, serum sickness (type 3 HPS), SE: headache, dyspnea, abdo pain |
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Etanercept
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subQ
recombinant TNF receptor, binds up TNF in the blood stream. increase the risk of spesis, TUBERCULOSIS, lymphoma and other cancers, multiple sclerosis, myelitis, optic neuritis. treat: RA, ankylosing spondylitis, psoriatic arthritis, juveline RA |
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Adalimumab
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subQ
Antibody directed against TNF-->decrease TNF levels treat: RA, ankylosing spondylitis, psoriatic arthritis, Crohn's dis. not approved for use in children SE: aplastic anemia, thrombocytopenia, leukopenia. increased risk of multiple sclerosis, myelitis, optic neuritis. may worsen heart failure |
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colchicine
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DOC: actue attacks of gout
bind tubulin-->inhibit the cell's ability to migrate to affected area, stop mitosis, inhibitng the synthesis adn relaease of leukotrienes contra: in prego, caution use with hepatic adn CVD |
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Allopurinol
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inhibits xanthine oxidase-->inhibiting uric acid production
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probenicid
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at high doses-->treat chrocin gout
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