Pharm Chapter 13 Bbc: Inhibitors Of Translation

Front 1

The bacterial ribosome is comprised of the 50s subunit and the 30s subunit, which antibiotics interfere with which subunit?

Back 1

50s: CEC (chloramphenicol, erythromycin, and clindamycin)
30s: TA (tetracycline and aminoglycosides)

Front 2

What type of bacteria (aerobic or anaerobic) do the aminoglycosides work in?

Back 2

Aerobic; aminoglycosides require oxygen-dependent transport across the membranes of the bacterium

ALSO gram negatives

Front 3

MOA of aminoglycosides?

Back 3

Bind to the 20s subunit of the ribosome and block the initial steps in protein syntesis and cause misreading of the mRNA code

Front 4

MOA of tetracyclines?

Back 4

Bind to the 30S subunit of the ribosome and block the acceptor site for incoming aminoacyl tRNA.

Front 5

Adverse effects of tetracyclines?

Back 5

Photosensitivty, promote the development of psuedotumor cerebri and prescribed with caution to obese,fertile women (another risk factor for psuedotumor). ALSO do NOT prescribe to children less than 8 years old OR in pregnant women BECAUSE of staining of permanent dentition

Front 6

Patient wants a glass of milk with their tetracycline - is this a problem?

Back 6

YES! antacids, iron and calcium must be avoided within a two-hour timeframe of infestinf any tetracycline since aluminum, magnesium, iron and calcium significantly impair absorption of the antibioic

Front 7

MOA of Chloremphenicol

Back 7

binds to the 50S subunit of the ribosome, physically blocking the action of peptidyl transferase - the enzyme needed to form the peptide bond between amino acids.

Front 8

What type of coverage (broad, gram negative, gram positive) does Chloremphenicol have?

Back 8

Broad especially affective against AEROBES

Front 9

Most notable AE of Chloremphenicol?

Back 9

Grey baby syndrome

also... inhibits P450, bone marrow toxic and can yield fatal aplastic anemia

Front 10

MOA of Erythromycin

Back 10

Binds to the 50S subunit blocking translocation so the amino acids cannot be shifted to their proper position in order to allow for peptide bond formation.

Front 11

What is erythromycin the DOC for?

Back 11

Penicillin allergic patients

Front 12

What specific infection is Erythromycin the DOC for?

Back 12

Mycoplasma pneumoniae

Front 13

AE of erythromycin?

Back 13

QT prolongation which can cause Torsades De Pointes; this risk is magnified with the use of P450 inhibitors at the same time

Front 14

What is SUPER important to remember about Clindamycin in terms of what/where it is used for treatment?

Back 14

Clindamycin is the DOC for ANAEROBIC INFECTIONS THAT OCCUR ABOVE THE DIAPHRAGM

Front 15

What is the DOC for anaerobic infections BELOW the diaphragm?

Back 15

Metronidazole