Pharm Ch.28 Test 2 Antiparkinsons Drugs

Front 1

____ is a general term that refers to a group of sx involving motor movement

Back 1

Parkinsonism

Front 2

slow movement

Back 2

bradkinesia

Front 3

sx of PD include ____ speech, the face taking on a mask-like and emotionless appearance, and _____ and swallowing difficulties

Back 3

slurred

chewing

Front 4

The pt assumes a rigid, ___-____ posture and the gait becomes unsteady and shuffled

Back 4

bent - forward

Front 5

All these Parkinson-like sx may be seen with the use of certain drugs, head injuries and ______.

Back 5

encephalitis

Front 6

Drugs used to tx PD are called _____ drugs

Back 6

antiparkinson

Front 7

These drugs either suppliment the _____ in the brain or block excess ____ so that better transmission of nerve impulses occurs

Back 7

dopamine

ACh

Front 8

______ are drugs that affect the dopamine content of the brain

Back 8

dopaminergics

Front 9

Examples of these drugs are:

Back 9

levodopa

carbidopa

or a combo of both

Front 10

The parkinson-like sx are caused by a ___ of dopamine in the CNS

Back 10

depletion

Front 11

_____ dopamine is difficult due to the blood brain barrier

Back 11

supplimenting

Front 12

_____ is a chemical formulation found implants and animals and is converted into dopamine by the body

Back 12

Levodopa

Front 13

levodopa used alone can cause -____ adverse reactions because too much stays in the PNS

Back 13

severe

Front 14

combining levodopa and _____ allows levodopa to reach the brain, which has a better therapeutic effect

Back 14

carbidopa

Front 15

carbidopa has __ effect when given alone

Back 15

no

Front 16

drugs that work to stimulate the dopamine receptors are called _____

Back 16

agonists

Front 17

The uses for dopaminergic drugs are:

Back 17

PD

PD like sx

RLS (restless leg syndrome)

viral infections (amantadine)

Front 18

Dry mouth and difficulty swallowing, anorecia, NV, abd.pain, constipation, increased hand tremor, HA and dizz are all ___ ____

Back 18

adverse reactions

Front 19

Severe adverse reactions to dopaminergic drugs include:

Back 19

Choreiform movements ( muscle twitching of limbs and face)

dystonic movements (muscle spasms affecting tongue, jaw, eyes, and neck)

Front 20

Levadopa is contraindicated in pt with __ ___ glaucoma and receiving MAOI _______

Back 20

narrow angled glaucoma

antidepressants

Front 21

Do not dopaminergic drugs with :

Back 21

antidepressants

antacids

anticonvulsants

Front 22

Foods high in _____ (vitamin B 6) or vitamine B6 preparations reduce the effect of levodopa

Back 22

pyridoxine

Front 23

It is thought that ___ ___ receptors act directly on postsynaptic dopamine receptors of nerve cells in the brain, mimicking the effects of dopamine in the brain

Back 23

nonergot dopamine

Front 24

dopamine receptor agonsits are used fot the tx of s/sx of ____

Back 24

PD

Front 25

It is also used for the tx of ____

Back 25

RLS

Front 26

The drug apomorphone (Apokyn) is used for the _-__ phenomena of PD

Back 26

on-off

Front 27

Common Adverse reactions include

Back 27

NV

dizz

somnolence, hallucinations, confusion, visual disturbances, postural hypotension, involuntary movements, HA

Front 28

There is an ____ risk of CNS depression when dopamine receptor agonists are administered with other CNS depressants

Back 28

increase

Front 29

another classification of antiparkinson drugs is the ____-___-_______ inhibitors

Back 29

Catechol-O-methyltransferase (COMT)

Front 30

These drugs are though to prolong the effect of levodopa by ___ the enzyme (COMT) which eliminates Dopamine

Back 30

blocking

Front 31

USed as ___ to levodopa/carbidopa in tx PD

Back 31

adjunct