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28 Cards in this Set
- Front
- Back
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Most frequent route of metabolism
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Hepatic enzymes
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Mechanisms of action for Phenytoin, Carbamazepine, Lamotrigine
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Sodium channel blockade
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MOA for benzodiazepines and barbiturates
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GABA-related targets
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MOA for Ethosuximide
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Calcium channels
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MOA for Valproic acid at high doses
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Affect calcium, potassium, and sodium channels
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Drugs of choice for generalized tonic-clonic and partial seizures
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Valproic acid and Phenytoin
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DOC for febrile seizures
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Phenobarbital
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Drugs of choice for absence seizures
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Ethosuximide and valproic acid
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Drug of choice for myoclonic seizures
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Valproic acid
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Drugs of choice for status epilepticus
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IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
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Drugs that can be used for infantile spasms
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Corticosteroids
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Anti-seizure drugs used also for bipolar affective disorder (BAD)
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Valproic acid, carbamazepine, phenytoin and gabapentin
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Anti-seizure drugs used also for Trigeminal neuralgia
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Carbamazepine
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Anti-seizure drugs used also for pain of neuropathic orgin
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Gabapentin
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Anti-seizure agent that exhibits non-linear metabolism, highly protein bound, causes fetal hydantoin syndrome, and stimulates hepatic metabolism
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Phenytoin
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SE of phenytoin
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Gingival hyperplasia, nystagmus, diplopia and ataxia
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Anti-seizure agent that induces formation of liver drug-metabolism enzymes, is teratogen and can cause craniofacial anomalies and spina bifida
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Carbamazepine
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Agent that inhibits hepatic metabolism, is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress
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Valproic acid
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Laboratory value required to be monitored for patients on valproic acid
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Serum ammonia and LFT's
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SE for Lamotrigine
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Stevens-Johnson syndrome
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SE for Felbamate
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Aplastic anemia and acute hepatic failure
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Anti-seizure medication also used in the prevention of migraines
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Valproic acid
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Carbamazepine may cause
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Agranulocytosis
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Anti-seizure drugs used as alternative drugs for mood stabilization
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Carbamazepine, gabapentin, lamotrigine, and valproic acid
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Why is ethosuximide given twice daily?
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to decrease GI upset
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SE of vigabatrin
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visual field defects
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which antiseizure drug is least likely to have withdrawal sx?
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ethosuximide
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DOC for bipolar after lithium
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Valproic acid
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