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22 Cards in this Set
- Front
- Back
Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol-oxidizing system (MEOS)
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Ethanol
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Agent with zero-order kinetics
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Ethanol
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Rate limiting step of alcohol metabolism
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Aldehyde dehydrogenase
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System that increases in activity with chronic ethanol exposure and may contribute to tolerance
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MEOS
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Enzyme that metabolizes acetaldehyde to acetate
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Aldehyde dehydrogenase
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Agents that inhibit acetaldehyde dehydrogenase
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Disulfiram, metronidazole, certain sulfonylureas and cephalosporins
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Agent used in the treatment of alcoholism, if alcohol is consumed concurrently, acetaldehyde builds up and results in nausea, headache, flushing, and hypotension
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Disulfiram
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The most common neurologic abnormality in chronic alcoholics
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Peripheral neuropathy (also excessive alcohol use is associated with HTN, anemia, and MI)
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Agent that is teratogen and causes a fetal syndrome
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Ethanol
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Agent that is the antidote for methanol overdose
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Ethanol, fomepizole
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Drug that inhibits alcohol dehydrogenase and is used in ethylene glycol exposure
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Fomepizole
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heavy drinking for 72 hours predisposes you to what?
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arrhythmia
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course of action for alcoholic presenting with truncal ataxia and ophthalmoplegia
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diazepam plus thiamine
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MEOS pathway will be maximally activated under condition of low concentrations of
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NAD+
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blood level of 500 mg/dL of alcohol is best characterized by…
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comatose and near death
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consumption of what red colored chemical causes blurred vision like a snowstorm and acidosis?
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methanol
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methanol is metabolized into what?
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formaldehyde and formic acid
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purpose of ethanol in methanol treatment?
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inhibit metabolic production of a toxic metabolite of the poison
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regular ingestion of moderate/heavy amounts of alcohol predisposes to hepatic damage after overdose of tylenol because ethanol…
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induces liver drug-metabolizing enzymes
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alcoholism increases risk for liver disease and what other disease process?
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heart failure
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combo of ethanol and disulfiram results in nausea/hypotension as a result of accumulation of what?
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acetaldehyde
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intense craving of alcohol while trying to recover can be ameliorated by a drug that is an?
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antagonist of opioid receptors
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