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22 Cards in this Set

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Agent that is metabolized to acetaldehyde by alcohol dehydrogenase and microsomal ethanol-oxidizing system (MEOS)
Ethanol
Agent with zero-order kinetics
Ethanol
Rate limiting step of alcohol metabolism
Aldehyde dehydrogenase
System that increases in activity with chronic ethanol exposure and may contribute to tolerance
MEOS
Enzyme that metabolizes acetaldehyde to acetate
Aldehyde dehydrogenase
Agents that inhibit acetaldehyde dehydrogenase
Disulfiram, metronidazole, certain sulfonylureas and cephalosporins
Agent used in the treatment of alcoholism, if alcohol is consumed concurrently, acetaldehyde builds up and results in nausea, headache, flushing, and hypotension
Disulfiram
The most common neurologic abnormality in chronic alcoholics
Peripheral neuropathy (also excessive alcohol use is associated with HTN, anemia, and MI)
Agent that is teratogen and causes a fetal syndrome
Ethanol
Agent that is the antidote for methanol overdose
Ethanol, fomepizole
Drug that inhibits alcohol dehydrogenase and is used in ethylene glycol exposure
Fomepizole
heavy drinking for 72 hours predisposes you to what?
arrhythmia
course of action for alcoholic presenting with truncal ataxia and ophthalmoplegia
diazepam plus thiamine
MEOS pathway will be maximally activated under condition of low concentrations of
NAD+
blood level of 500 mg/dL of alcohol is best characterized by…
comatose and near death
consumption of what red colored chemical causes blurred vision like a snowstorm and acidosis?
methanol
methanol is metabolized into what?
formaldehyde and formic acid
purpose of ethanol in methanol treatment?
inhibit metabolic production of a toxic metabolite of the poison
regular ingestion of moderate/heavy amounts of alcohol predisposes to hepatic damage after overdose of tylenol because ethanol…
induces liver drug-metabolizing enzymes
alcoholism increases risk for liver disease and what other disease process?
heart failure
combo of ethanol and disulfiram results in nausea/hypotension as a result of accumulation of what?
acetaldehyde
intense craving of alcohol while trying to recover can be ameliorated by a drug that is an?
antagonist of opioid receptors