Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
|
Irreversible, (long acting) non selective A blocker used for presurgical mgmt of pheocromocytoma, or mgmt of hypertension.
|
Phenoxybenzamine, slight A1 selectivity.Has Serotonin blocking effects, can be used for carcinoid tumor, and has H1 blocking effects and can be used for mastocytosis
|
|
|
Reversible, shorter acting non selective A blocker. Reduces vascular tone of arteries and veins
|
Phentolamine
|
|
|
Side effects and toxicities associated with non selective A blockers
|
compensatory tachycardia, due to baroreceptor reflex
|
|
|
Drug used prevent tissue ischemia and necrosis due to epinephrine.
|
Phentolamine
|
|
|
Drug used to treat rebound hypertension caused by abrupt clonidine termination
|
Phentolamine
|
|
|
Side effects associated with A1 selective antagonists
|
orthostatic hypotension associated with first few doses
|
|
|
A1 selective blockers, used to treat hypertension:
|
Prazosin, Doxazosin, and terazosin. Cause less compensatory tachcardia than non selectives
|
|
|
A1 selective antagonists commonly used for urinary hesitancy in men with BPH
|
Tamsulosin and silodosin
|
|
|
To minimize orthostatic hypotensive effects of the A1 selective antagonists, what should the patient do?
|
Take a smaller first dose, and do it right before going to bed
|
|
|
What are the B1 selective antagonists, used for Hypertension, that have an advantage in patients with asthma?
|
Metoprolol, Acebutolol, Atenolol, Esmolol
|
|
|
Which B blockers have a partial agonist activity, and are also used in patients with asthma due to a lessened bronchospasm effect
|
Pindolol, Acebutolol
|
|
|
Which antagonists have a combined effect, due to optical activity, the diferent isomers acting on either A or B receptors
|
Labetelol and carvedilol
|
|
|
A beta blocker without a local anesthetic reflex that can be used topically in patients with glaucoma
|
Timolol
|
|
|
What is the shortest acting ester B blocker, and is used only parenternally?
|
Esmolol
|
|
|
What is the longest acting B blocker?
|
Nadolol
|
|
|
Which B blockers are less lipid soluble and probably enter the CNS to a lesser extent
|
Acebutolol, Nadolol, and Atenolol
|
|
|
Which B blockers can reduce morbidity and mortality when used properly in heart failure?
|
Labetalol, carvedilol, and metoprolol
|
|
|
Which combined A and B blocker is sometimes used to treat Pheocromocytomas secreting large amounts of epinephrine and norepinephrine?
|
Labetalol
|
|
|
Blockage of symptoms of hypoglycemia in cases of insuilin overdose is a major problem with these drugs.
|
B Blockers
|
|
|
Toxic effects of B Blockers
|
can cause bronchospasm in asthmatics, atrioventricular blockade, bradycardia, as well as sexual dysfunction
|
|
|
B blocker with a high lipid solubility that can enter the CNS readily. is prototype B blocker
|
Propanolol
|
|
|
B Blocker with a high lipid solubility that easily enters the CNS. Is used to treat angina, arrythmias, hypertension, tremor, stagefright, and migraine
|
Propanolol
|
