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33 Cards in this Set
- Front
- Back
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3 drugs that inhibit platelet aggregatation?
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aspirin (@COX1)
clopidogrel/ticlopene (@ADP) Abciximab/Integrelin (@intengrin) |
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Only inhibits factor X?
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LMWH (enoxaparin, dalteparin)
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enoxaparin?
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LMWH
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Inhibits factor X as well as activating ATIII?
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Heparin
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Mechanism of heparin
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Primarily activated ATIII to inhibit factors II, VII, IX, and X.
Secondarily, directly inhibits factor X |
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Competitive antagonist of vit K reductase?
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warfarin/coumadin = TERATOGENIC
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Oral anticoagulant?
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warfarin/coumadin
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Fibrinolytic drugs?
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"clot busters"
tPA streptokinase plasminogen -->plasmin |
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Do nitrates decrease preload, afterload, or neither?
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They decrease both via veno and arterio dilation
Side effects: reflex bradycardia TOLERANCE (couple hours) |
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Treatment for stable angina?
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Nitrates
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Treatment for unstable angina?
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Ca channel blockers:
diltiazam verapamil Beta-blockers |
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Mechanism of Ca channel blockers?
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vasodilation (smooth muscle relaxation)
neg ionotropes neg chronotropes |
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What type of angina do you treat with dihydropyridine?
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Prinzmetal's
Dihydropyridine only acts as a vasodilator |
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How do bile acid sequestrants work?
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They (cholestyramine) bind bile in the gut preventing reabsorption. The liver inc production of bile, creating demand for cholesterol. To meet this demand there are inc ldl receptors on the liver, which clear the ldl from the plasma. DECREASES LDL.
Also inc TG. |
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Should you use cholestyramine in someone who has hypertriglyceremia?
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NO, bile acid sequestrants (cholestryramine) inc TG's.
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Drug that increases HDL?
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Niacin
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HMG-CoA reductase?
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Statins
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Drug of choice to decrease LDL?
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Statins
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Used to decrease TG?
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Gemfibrozil
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Tx for HTN in a diabetic?
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Captopril
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Side effects of ACE i's?
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cough, rash, dry skin...mediated via brakykin
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Difference between ACEi's and ARB's?
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Besides mechanism, arb's have less side effects i.e NO cough
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Classes of antiarrhythmics?
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Class I: Na blockers
A = mod Na block B = mild Na block C = strong Na block Class II: Beta Blockers Class III: K blockers Class IV: Ca Channel blockers Adenosine |
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Class I anti-arrhythmics?
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IA = quinidine, procainamide
IB = lidocaine IC = flecanide = NEVER USE |
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What is the effect of beta-blockers in terms of anti-arrhythmics?
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Decrease AV nodal conductance.
Use for A-fib |
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#1 drug for a-fib/flutter? Drawback?
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Amiodarone (Class I, II, III, IV, primarily class III)
Tons of side effects. |
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Tx for paroxsysmal supraventricular tachycardia?
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Adenosine
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What are two targets of treating angina?
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Decrease O2 demand
Increase O2 supply |
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Inhibit's Na/K ATPase to increase ionotropy?
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Digoxin/Digitalis
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Ways to treat CHF?
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Increase ionotropy
Decrease afterload |
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Drugs that decrease mortality when treating CHF?
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B-blockers, ACE i's/ARB's, Spironalactone
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Tx CHF by inc ionotropy?
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Digitalis/Digoxin
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Symptomatic improvement in CHF?
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diuretics
digoxin nitrates |
