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23 Cards in this Set
- Front
- Back
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Levodopa
Type? Application? Contras? Adverse? |
Dopamine precursor
Parkinsons Effects: dyskinesia, heart diseas, orthostatic HTN Cx: melanoma, glaucoma, MAO-Is |
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Levodopa
therapeutic type? |
needs carbidopa
tolerance Dopamine pre-cursor |
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Bromocroptine
Pergoglide Type? Application? Contras? Adverse? |
Dopamine Receptor Agonist
parkinsons, galactorrhea seizures Cx uncontrolled HTN |
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bromocriptine
pergoglide therapuetic? Receptors targeted? |
ergot alkaloid
Bromo: D2 agonist Pergolide: D1, D2 dopamine agonist Act primarily on |
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Pramipexole
Ropinirole Type? Application? Contras? Adverse? |
Dopamine Receptor Agonist
parkinsons dyskineisa, orthostatic htn Cx: other sedatives |
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Pramiprol
Ropinirole therapeutics? Receptor Targets? |
dopa agonists thathave half lives longer than that of levo
non-ergot Pramiprol: D3 Ropinirole: D3 |
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Rasagiline
Selegiline Type? Application? Contras? Adverse? |
Inhibit Dopamine Metabolism
Parkinsons AE: BBB, GI hemorrhage Cx: cyclobenzaprine dextromethorphan meperidine |
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Rasagiline
Selegiline Therapeutics? Type? |
MAO blockers
selegiline: MAOB selective at low doses.. toxic metabolite amphetamine rasagiline: MAOB no metabolite |
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Tolcapone, Entacapone
type? Application? Contras? Adverse? |
COMT blockers.. prevent degradation of DOPA to DOPAC to HVA
parkinsons dyskinesia hallucinations Cx: rhabdomyelosis liver disease |
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Entacapone
Tolcapone therapeutics |
tolca: BBB crosser, COMT inhib
entaca: non-BBB COMT inhib |
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Amantadine
type? Application? Contras? Adverse? |
Inhibits NMDA receptors
parkinsons, influenza A neuroleptic malignant syndrome Cx: hypersens |
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Amantadine
therapeutics? Type? |
treats levodopa dyskinesia
inhibits NMDA receptors |
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trihexyphenindyl, benzotropine
type? Application? Contras? Adverse? |
Muscarinic receptor antagonists
parkinsons SEs: intraocular pressure Cx: narrow angle |
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Major metabolite excreted in urine of Dopa degradation?
2 pathways.. 2 breakdown enzymes.. |
Homovanillistic acid (HVA)
1. COMT DOPA > 3MD > HVA 2. MAO DOPA > DOPAC > HVA |
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D1 dopamine receptor
Distribution? Activity? |
striatum, neocortex
excitatory |
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D2 dopamine receptor
Distribution? Activity? |
Striatum, SN, anterior pituitary gland
inhibitory |
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D3 dopamine receptor
Distribution? Activity? |
Nucleus Accumbens (reward center), Hypothalamus
inhibitory |
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D4 dopamine receptor
Distribution? Activity? |
Frontal Cortex, Medulla Midbrain
inhibitory |
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D5 dopamine receptor
Distribution? Activity? |
Hippocampus, Hypothalamus
excitatory |
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excitatory D1 type dopamine receptors do..?
inhibtory D2 type dopamine receptors do...? |
E: increase cAMP, PIP2 (in Ca++, increase PKC)
I: dec cAMP, Increas K+, decrease Ca++ |
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transporter that moves L-Dopa into brain?
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long-chain neutral amino acid transporter (saturable)
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Rate limiting step in dopamine synthesis?
Enzyme that turns L-DOPA to Dopamine? (+co-factors) |
Tyorsine to L-DOPA (tyrosine hydroxylase)
AADC (aromatic L-amino acid decarboxylase) target for carbidopa |
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Dopamine to NORE..
enzyme and cofactors? location. |
Dopamine Beta-hydroxylase
vitaminc C |
