Pharm B219 - Unit 1 - Vocab

Front 1

pharmacokinetics

Back 1

the study of drug movement through the body

Front 2

pharmacodynamics

Back 2

the study of the effects of drugs on the body and how these effects are produced

Front 3

absorption

Back 3

the movement of a drug from the site of administration into the blood

Front 4

distribution

Back 4

the movement of drugs through the bloodstream, into the tissues, and eventually into the cells

Front 5

metabolism

Back 5

enzymatic alteration of a drug into another substance or substances

Front 6

excretion

Back 6

removal of drugs from the body

Front 7

therapeutic index

Back 7

a measure of drug safety, the ratio of a drug’s lethal dose to its effective dose

Front 8

generic

Back 8

a drug’s nonproprietary name

Front 9

contraindication

Back 9

situations when a drug should not be used, or must be used with very careful monitoring

Front 10

enteral

Back 10

administration by way of the gastrointestinal tract

Front 11

parenteral

Back 11

administration outside the gastrointestinal tract, by injection

Front 12

induction/liver inducers

Back 12

the process of stimulating liver enzyme production

Front 13

maximal efficacy

Back 13

the largest effect a drug can produce

Front 14

potency

Back 14

the amount of drug necessary to produce an effect

Front 15

affinity

Back 15

the strength of attraction between a drug and its receptor

Front 16

anaphylaxis

Back 16

systemic, life-threatening allergic reaction

Front 17

agonist

Back 17

a drug that activates receptors

Front 18

antagonist

Back 18

a drug that binds to a receptor and prevents receptor activation by endogenous compounds

Front 19

potentiation

Back 19

the intensification of one drug’s effects by another drug

Front 20

adverse effect

Back 20

any drug effect other than the desired therapeutic effect

Front 21

first-pass phenomenon

Back 21

rapid hepatic inactivation of a drug following oral administration

Front 22

physical dependence

Back 22

adaptation to prolonged drug exposure where an abstinence syndrome results from discontinuing drug use

Front 23

tolerance

Back 23

requiring increased drug levels/doses to produce the same effect following long-term administration

Front 24

plateau/steady state

Back 24

constant drug blood level where administration rate equals elimination rate