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19 Cards in this Set
- Front
- Back
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Hemorrhagic cystitis
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Cyclophosphamide
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Leucovorin rescue
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Methotrexate
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Thymidylate synthase
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5-FU
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Thymineless death
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5-fluorouracil (5-FU)
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Xanthine oxidase (allopurinol interaction)
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6-mercaptopurine (6-MP)
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HPGRT
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6-mercaptopurine (6-MP), 6-thioguanine (6-TG)
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Covalent modification of N7 guanine
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Alkylating agents
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Mesna
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Cyclophosphamide
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Brain tumors and neurotoxicity
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Nitrosoureas
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Nephrotoxicity (mannitol)
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Cisplatin
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Non-myelosuppressive
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Cisplatin
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Topoisomerase I inhibitors
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Camptothecins (topotecan, irinotecan)
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Topoisomerase II inhibitors
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Podophyllotoxins (etoposide, teniposide)
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Irreversible cumulative cardiac toxicity
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Anthracyclines (daunorubicin, doxorubicin)
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Pulmonary toxicity
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Bleomycin
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CCS intercalator/strand breaker
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Bleomycin
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Prevents microtubule polymerization (assembly)
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Vinca alkaloids (vincristine, vinblastine)
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Causes stabilization of microtubule polymerization (prevents disassembly)
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Taxanes (paclitaxel, docetaxel)
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High neurotoxicity (areflexia, peripheral neuritis, paralytic ileus)
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Vincristine
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