Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
23 Cards in this Set
- Front
- Back
AZT activation
|
Zidovudine (AZT) & Stavudine (d4T) need host Thymidine Kinase
|
|
CMV Tx first and second line
|
CMV Tx: Gancyclovir, 2nd line Cidofovir, either Rx can be used +/- Foscarnet
|
|
Cervarix protects against what serotypes
|
Cervarix vaccinates against HPV 16 and 18, using HPV L1 protein
|
|
Cidofovir Indication and S/E
|
Cidofovir (2nd line for CMV) is neprhotoxic, use Probenecid to avoid ARF
|
|
Cidofovir S/E and Treatment
|
Cidofovir (used for CMV) is neprhotoxic, use Probenecid to avoid ARF
|
|
Cidofovir activation
|
Cidofovir does not need activation
|
|
Describe the HPV vaccines
|
HPV
|
|
Foscarnet Indications
|
Foscarnet is used in acyclovir-resistant HSV and gancyclovir resistant CMV
|
|
Foscarnet MOA
|
Foscarnet is analog of pyrophosphate, it binds to pyrophosphate site of DNA polymerase, inhibiting it
|
|
Gardasil protects against what serotypes?
|
Gardasil vaccinates against HPV 6, 11, 16, 18 using HPV L1 protein
|
|
HIV drug most likely to cause lactic acidosis
|
Stavudine (d4T) MC HIV med a/w lactic acidosis, didanosine (DDI) & Zidovudine uncommon lactic acidosis
|
|
Influenza Tx
|
Oseltamivir & Zanamivir (inhaled only) neuraminidase inhibitors [Amantadine Tx influ A only]
|
|
Is there cross resistance between NNRTIs, NRTIs, and PIs?
|
There is no cross resistance between NNRTIs, NRTIs, and PIs
|
|
List Antiviral Activation pathways
|
Zidovudine (AZT) & Stavudine (d4T) need host Thymidine Kinase, Acyclovir needs viral thymidine kinase, Ganciclovir needs phophotransferase UL97. Cidofovir needs no activation.
|
|
Name 3 HIV meds known for causing peripheral neuropathy
|
HIV meds a/w peripheral neuropathy: ddI, d4T, AZT
|
|
Ribavirin Indications & BBW
|
Ribavirin indicated for HCV& RSV, BBW: hemolytic anemia, tetragenic, & not HCV monotherapy
|
|
Severe RSV Tx
|
Severe RSV Tx is Ribavirin (guanosine analog)
|
|
Stavudine (d4T) BB warnings
|
Stavudine (d4T) BB: lactic acidosis & pancreatitis
|
|
Which Antivirals require host Thymidine Kinase to be activated?
|
Zidovudine (AZT) & Stavudine (d4T) need host Thymidine Kinase
|
|
Which Antivirals require viral Thymidine Kinase for activation?
|
Acyclovir requires Thymidine Kinase for activation
|
|
Which HIV med is most likely to cause anemia?
|
Zidovudine (AZT) most likely HIV med to cause BM suppression & anemia
|
|
Which antivirals require Phosphotransferase UL97 for activation?
|
Ganciclovir needs phophotransferase UL97
|
|
d4T activation
|
Zidovudine (AZT) & Stavudine (d4T) need host Thymidine Kinase
|