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23 Cards in this Set

  • Front
  • Back
AZT activation
Zidovudine (AZT) & Stavudine (d4T) need host Thymidine Kinase
CMV Tx first and second line
CMV Tx: Gancyclovir, 2nd line Cidofovir, either Rx can be used +/- Foscarnet
Cervarix protects against what serotypes
Cervarix vaccinates against HPV 16 and 18, using HPV L1 protein
Cidofovir Indication and S/E
Cidofovir (2nd line for CMV) is neprhotoxic, use Probenecid to avoid ARF
Cidofovir S/E and Treatment
Cidofovir (used for CMV) is neprhotoxic, use Probenecid to avoid ARF
Cidofovir activation
Cidofovir does not need activation
Describe the HPV vaccines
HPV
Foscarnet Indications
Foscarnet is used in acyclovir-resistant HSV and gancyclovir resistant CMV
Foscarnet MOA
Foscarnet is analog of pyrophosphate, it binds to pyrophosphate site of DNA polymerase, inhibiting it
Gardasil protects against what serotypes?
Gardasil vaccinates against HPV 6, 11, 16, 18 using HPV L1 protein
HIV drug most likely to cause lactic acidosis
Stavudine (d4T) MC HIV med a/w lactic acidosis, didanosine (DDI) & Zidovudine uncommon lactic acidosis
Influenza Tx
Oseltamivir & Zanamivir (inhaled only) neuraminidase inhibitors [Amantadine Tx influ A only]
Is there cross resistance between NNRTIs, NRTIs, and PIs?
There is no cross resistance between NNRTIs, NRTIs, and PIs
List Antiviral Activation pathways
Zidovudine (AZT) & Stavudine (d4T) need host Thymidine Kinase, Acyclovir needs viral thymidine kinase, Ganciclovir needs phophotransferase UL97. Cidofovir needs no activation.
Name 3 HIV meds known for causing peripheral neuropathy
HIV meds a/w peripheral neuropathy: ddI, d4T, AZT
Ribavirin Indications & BBW
Ribavirin indicated for HCV& RSV, BBW: hemolytic anemia, tetragenic, & not HCV monotherapy
Severe RSV Tx
Severe RSV Tx is Ribavirin (guanosine analog)
Stavudine (d4T) BB warnings
Stavudine (d4T) BB: lactic acidosis & pancreatitis
Which Antivirals require host Thymidine Kinase to be activated?
Zidovudine (AZT) & Stavudine (d4T) need host Thymidine Kinase
Which Antivirals require viral Thymidine Kinase for activation?
Acyclovir requires Thymidine Kinase for activation
Which HIV med is most likely to cause anemia?
Zidovudine (AZT) most likely HIV med to cause BM suppression & anemia
Which antivirals require Phosphotransferase UL97 for activation?
Ganciclovir needs phophotransferase UL97
d4T activation
Zidovudine (AZT) & Stavudine (d4T) need host Thymidine Kinase