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31 Cards in this Set
- Front
- Back
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Oseltamivir use
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Tx symptoms influenza
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Oseltamivir MOA
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NA inhibitor
prevents budding of HINI and H5NI |
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Foscarnet uses
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i.v. only
DOC CMA resistant to gancyclovir and cidofovir HSV, CMV, HIV |
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RNA and DNA polymerase inhibitor
Tx CMV |
Foscarnet (i.v.)
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Tx CMV resistant to cidofovir
not a prodrug |
Foscarnet (i.v.)
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DOC CMV retinitis
(occular implant) |
Gancyclovir
prodrug guanosine |
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Not a prodrug
Binds mRNA as terminator |
Fomivirsen
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mRNA termination
CMV treatment |
Forivirsen
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Fomivirsen
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mRNA terminator
Tx CMV |
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DOC Herpes Keratitis
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Trifluridine
(opthalmic solution) |
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Trifluridine
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opthalmic solution
DOC Herpes Keratitis |
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HIV
Fusion Inhibitors |
Enfurtide
(gp41, for last case decrease titer) Maraviroc (CCR5 only, gp120) |
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Maraviroc
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fusion inhibitor (HIV)
gp120 binds CCR5 tropic only |
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Enfuvirtide
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last resort drug to lower HIV titer
bind gp41 low T 1/2 |
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CCR5 tropic drug only
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Maravioc
fusion inhibitor (gp120) |
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NRTIs
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Lamividine
Abacavir Tenofovir Emtricitabine Zidovidine |
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Zidovudine
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NRTI
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Lamivudine
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NRTI
also HBV |
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Abacavir
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NRTI
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Tenofovir
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NRTI
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Emtrictabine
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NRTI
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NRTI works even when resistant ot other NRTI
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Tenofovir
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NRTI resistance v. NNRTI resistance
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NNRTI will all be resistant
NRTI have diff. mechanisms |
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NNRTIs
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Nevirapine
Efavirenz |
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Integrase Inhibitors
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Raltegravir
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Ralegravir
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Integrase Inhibitors
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Nevirapine
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NNRTI
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Efavirenz
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NNRTI
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Protease Inhibitors
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Ritonavir + Lopinavir
Atazanivir |
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Ritonavir-Lopinavir
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Protease Inhibitors
Rotonavir decreases CPY3A4 increase Lopinavir in plasma |
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Atazanavir
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Protease inhibitor
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