Pharm - Antiviral Agents

Front 1

NRTI prototype and MOA

Back 1

zidovudine; activated by cell enzymes, competitively inhibit HIV-1 RT and incorporate into viral DNA chain causing termination

Front 2

NNRTI prototype and MOA

Back 2

delavirdine; binds HIV-1 RT to inhibit RNA/DNA dep DNA polymerase binding

Front 3

Protease inhibitor prototype and MOA

Back 3

indinavir; prevents cleavage of Gag-Pol polypeptide resulting in production of immature, noninfectious viral particles

Front 4

Fusion inhibitor prototype and MOA

Back 4

enfuvirtide; binds gp41 subunit to prevent conformational change needed to fuse with cell mem

Front 5

Integrase inhibitor prototype and MOA

Back 5

raltegravir; binds integrase to inhibit strand transfer which interferes with HIV DNA integration into host cell chromosome

Front 6

Drug used to tx HBV and HCV

Back 6

interferon alfa

Front 7

DOC for influenza A

Back 7

Amantadine

Front 8

DOC for RSV

Back 8

Ribavirin

Front 9

DOC for CMV retinitis

Back 9

Ganciclovir

Front 10

SE for ganciclovir

Back 10

Neutro, leuko and thrombocytopenia

Front 11

Anti-viral agents associated with Stephen Johnson syndrome

Back 11

Nevirapine, amprenavir

Front 12

HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism

Back 12

Protease inhibitors

Front 13

Antivirals that are teratogens

Back 13

Delavirdine, efavirenz, and ribavirin

Front 14

Antivirals associated with neutropenia

Back 14

Ganciclovir, zidovudine, saquinavir, and interferon

Front 15

HIV med used to reduce transmission during birth

Back 15

AZT (zidovudine)

Front 16

MOA and use of adefovir dipivoxil

Back 16

activated by phosphorylation, competitively inhibits HBV DNA polymerase and incorporates into viral DNA causing chain termination; tx of HBV

Front 17

MOA and use of entecavir

Back 17

competitively inhibits all 3 functions of HBV DNA polymerase; tx HBV

Front 18

Indications (2) for lamivudine

Back 18

HIV, HBV

Front 19

Indications (2) for tenofovir

Back 19

HIV, HBV

Front 20

Drug used to tx HCV and MOA

Back 20

ribavirin; interferes with synthesis of guanosine triphosphate, inhibits capping of mRNA and inhibits viral RNA-dep polymerase of certain viruses

Front 21

anti-influenza agents active only against type A; MOA

Back 21

amantadine and rimantadine; blocks M2 proton ion channel of virus to inhibit uncoating

Front 22

anti-influenza agents active against type A and B; MOA

Back 22

oseltamivir and zanamivir; reversibly interacts with neuraminidase to inhibit activity to interfere with progeny release, destroys receptors recognized by viral hemagglutinin