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6 Cards in this Set
- Front
- Back
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Amphotericin B MOA
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Interacts with Ergosterol (pores in membranes)
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Flucytosine MOA
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Converted to 5-FU by fungal deaminase
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Griseofulvin Indication
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Topical dermatophytes, even though taken orally
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Ketoconazole S/E
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Inhibits P450, hepatotoxic, Decr steroid synthesis (cortisol & T)
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Ketokonazole MOA
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Inhibits ergosterol synthesis (14a-demethylase, a fungal P450)
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Terbinafine MOA & S/E
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Inhibits Squalene epoxidase -> Decr ergosterol; S/E is hepatoxicity
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