Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
MACROLIDES
Mechanism of action and resistance |
•Inhibit Protein Syn; Bind 50S inhibit translocation
•Methyltransferases alter binding site |
|
|
CHLORAMPHENICOL
Mechanism of action and resistance |
•Inhibit Protein Syn; Bind 50S inhibit transpeptidation
•Inactivating acetyltransferases |
|
|
TETRACYCLINES
Mechanism of action and resistance |
•Inhibit Protein Syn; Bind 30S prevent binding tRNA
•Pump out |
|
|
AMINOGLYCOSIDES
Mechanism of action and resistance |
•Inhibit Protein Syn; Bind 30S block initiation, incorporate wrong AA
•Acetyl, phosphoryl or adenylyl conjugation |
|
|
FLUOROQUINOLONES
Mechanism of action and resistance |
•Inhibit topoisomerase
•Change TE sensitivity, pump out |
|
|
RIFAMPIN
Mechanism of action and resistance |
•Inhibit Protein Syn; inhibits DNA dependent RNA poly
•Change in enzyme |
|
|
SULFONAMIDES
Mechanism of action and resistance |
•Inhibit Wall Syn; inhibit folic acid syn
•Decreased sensitivity of target enzyme, increased PABA formation, use of exogenous folate |
|
|
BETA LACTAMS
Mechanism of action and resistance |
•Inhibit Wall Syn
•Penicillinase, modification of PBPs, change of porins |
|
|
VANCOMYCIN
Mechanism of action and resistance |
•Inhibit Wall Syn; inhibit peptidoglycan chain elognation
•Change in pentapeptide, D-ala-D-lactate |
