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24 Cards in this Set
- Front
- Back
MOA
Typical Antipsychotics |
Block Dopamine type 2 post-synaptic receptors
in the mesolimbic-mesocortical pathways |
|
7 Low potency Anti-psychotics
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Perphenazine
Prochlorperazine Mesoridazine Molindone Chlorpromazine Loxapine Thioridazine |
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5 High Potency Anti-psychotics
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Fluphenazine
Pimozide Haloperidol Thiothixene Trifluoperazine |
|
SE of Low Potency Anti-psychotics
|
More sedation, hypotension and seizure-threshold reduction
|
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SE of High Potency Anti-psychotics
|
More Movement disorders (EPS)
|
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MOA of Atypical Antipsychotics
|
Same as typicals but also block one or more additional dopamine receptors (D1,3,4,5)
More blocking of 5-HT2 and D2 receptors than typical agents |
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DOC for Recurrent Suicidal Behavior
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Clozapine
|
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DOC for Tourette's Syndrome
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Pimozide
|
|
SE due to muscarinic effects (anticholinergic)
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Dry Mouth
Constipation Urinary Retention Blurred Vision Sedation |
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SE due to Alpha-adrenergic effects
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Orthostatic hypotension
Impotency/ejaculation interference |
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SE due to Histamine effects
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Sedation
|
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SE due to Dopamine effect
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Hyperprolactinemia (all typicals; some atypicals)
Hypothalamic effects Extra-pyramidal symptoms |
|
Given prophylactically for EPS
|
Benztropine
|
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Used to tx EPS
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Benztropine (also used prophylactically)
Diphenhydramine Trihexyphenidyl |
|
Big SE of Clozapine
|
Agranulocytosis
Monitor WBC |
|
3 Anti-psychotics that cause increase risk of stroke
|
Olanzapine
Raliperidone Risperidone |
|
1 Anti-psychotic Inhibition of Ejaculation
|
Thioridazine
|
|
Anti-psychotic that causes poikilothermia
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Chlorpromazine (some other typicals)
|
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Anti-psychotics that have high weight gain/Hyperglycemia/hyperlipidemia
|
Clozapine
Olanzapine |
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Anti-Psychotics that lower seizure threshold
|
Clozapine
chlorpromazine Olanzapine |
|
2 Most effective antipsychotics
|
Clozapine
Olanzapine |
|
Severe, dangerous non-compliance managed with injectable agents (3 of them)
|
Haloperidol decanoate
Fluphenazine decanoate Risperidone microspheres (the one atypical) |
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DOC combo Psychotic Depression
|
Combo
olanzapine/fluoxetine |
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Only antipsychotic with anti-suicidal actions
|
Clozapine
|