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24 Cards in this Set

  • Front
  • Back
MOA
Typical Antipsychotics
Block Dopamine type 2 post-synaptic receptors
in the mesolimbic-mesocortical pathways
7 Low potency Anti-psychotics
Perphenazine
Prochlorperazine
Mesoridazine
Molindone
Chlorpromazine
Loxapine
Thioridazine
5 High Potency Anti-psychotics
Fluphenazine
Pimozide
Haloperidol
Thiothixene
Trifluoperazine
SE of Low Potency Anti-psychotics
More sedation, hypotension and seizure-threshold reduction
SE of High Potency Anti-psychotics
More Movement disorders (EPS)
MOA of Atypical Antipsychotics
Same as typicals but also block one or more additional dopamine receptors (D1,3,4,5)

More blocking of 5-HT2 and D2 receptors than typical agents
DOC for Recurrent Suicidal Behavior
Clozapine
DOC for Tourette's Syndrome
Pimozide
SE due to muscarinic effects (anticholinergic)
Dry Mouth
Constipation
Urinary Retention
Blurred Vision
Sedation
SE due to Alpha-adrenergic effects
Orthostatic hypotension
Impotency/ejaculation interference
SE due to Histamine effects
Sedation
SE due to Dopamine effect
Hyperprolactinemia (all typicals; some atypicals)
Hypothalamic effects
Extra-pyramidal symptoms
Given prophylactically for EPS
Benztropine
Used to tx EPS
Benztropine (also used prophylactically)
Diphenhydramine
Trihexyphenidyl
Big SE of Clozapine
Agranulocytosis

Monitor WBC
3 Anti-psychotics that cause increase risk of stroke
Olanzapine
Raliperidone
Risperidone
1 Anti-psychotic Inhibition of Ejaculation
Thioridazine
Anti-psychotic that causes poikilothermia
Chlorpromazine (some other typicals)
Anti-psychotics that have high weight gain/Hyperglycemia/hyperlipidemia
Clozapine
Olanzapine
Anti-Psychotics that lower seizure threshold
Clozapine
chlorpromazine
Olanzapine
2 Most effective antipsychotics
Clozapine
Olanzapine
Severe, dangerous non-compliance managed with injectable agents (3 of them)
Haloperidol decanoate
Fluphenazine decanoate
Risperidone microspheres (the one atypical)
DOC combo Psychotic Depression
Combo
olanzapine/fluoxetine
Only antipsychotic with anti-suicidal actions
Clozapine