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20 Cards in this Set

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  • Back
Cyclosporine
80. Protects against rejections from organ transplants 81. Does not induce bone marrow depression
Cyclophosphamide
82. Alkylating agent of both purine & pyrimidine bases of DNA 83. Txt CLL
Cisplatin’s toxicities
84. Nephro- & Ototoxicity
Methotrexate
85. Antimetabolite of folic acid: (-)dihydrofolate reductase
Leucovorin Rescue
86. Can block/reduce Methotrexate = inc. folic acid via a reduced folate
Bleomycin toxicities
87. Pneumonitis & pulmonary fibrosis
Azathiorine
88. Used in organ transplantation = kidney allografts 89. Allopurinol can inc. its activity by (-) its biotransformation to xanthine oxidase
MOPP
90. Chemotherapy used in the txt of Hodgkin ‘s disease 91. M = Mechlorethamine – nitrogen mustard 92. O = Oncovin (Vincristine) – prevents microtubule assembly 93. P = Procarbazine 94. P = Prednisone – glucocorticoid, inducing apoptosis
Tamoxifen
95. (-) estrogen receptor 96. Txt of breast tumors, can see associated endometrial CA
Flutamide
97. Antiandrogenic 98. Used w/ Leuprolide (LH-RH analog) 99. Txt prostatic CA
Megestrol
100. (-) progesterone receptor 101. Txt endometrial CA
Fluoxymesterone
102. Androgenic steroid 103. Txt mammary CA in postmenopausal women
Methotrexate
104. Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase 105. Txt of ALL 106. Txt of Psoriasis
Brain tumor Txt
107. Lomustine 108. Carmustine – Causes pulmonary fibrosis
Streptozocin
109. Attaches to â cells 110. Txt of pancreatic insulinomas
Cytarabine (AraC)
111. Pyrimidine analog 112. DOC for AML
Dactinomycin
113. Used for Wilms tumor & rhabdomyosarcoma
Etoposide
114. Used for oat cell CA
Paclitaxel
115. Used for ovarian CA
Amifostine
116. Can dec. nephrotoxicity due to chronic use of Cisplatin