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14 Cards in this Set
- Front
- Back
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Bicalutamide
Nilutamide Flutamide MOA |
block androgen rec.
-always give w/ GnRH analog to prevent (+) testosterone |
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effects blood
Bicalutamide |
(+) testosterone and LH
-give w/ GnRH analog to prevent |
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prefer Bicalutamide for androgen rec. block
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-less hepatic toxicity
-taken 1qd |
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Spirinolactone MOA
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aldosterone rec. antagonist
(-) testosterone synthesis (+) partial estrogen and progesterone rec. treat hirsituism in females |
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GnRH rec. agonists
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Lupron (depot i.m.)
Gosrelin acetate (implant 3mo.) Nafarelin acetate (intranasal bid) Gonadorelin- i.v. or s.c. |
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GnRH effects
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-initial (+) testosterone, LH, FSH
-continuous = (-) due to GnRH rec. non-pulsatile |
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GnRH analog uses
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-prostatic carcinoma
-precocious puberty -endometriosis/ fibroid tumors |
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Cetrolix
Degarlix |
GnRH antagonists
Tx: advanced prostatic cancer |
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a1-rec. antagonists
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-terazoin
-doxazoin -tamsulosin |
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a1-rec. antagonists MOA
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-terazoin/ tansulodin/ doxazoin
reversible relaxation of sm muscle decrease R to flow |
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Tx HTN and BPH
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terazoin (T50= 12h)
doxazoin (T50= 22h) |
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Tamsulosin
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a1-rec. antagonist
-better to avoid orthostatic hypotension and dizziness -worse for impotence |
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5a-reductase (-)
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finisteride
dutasteride prevent conversion of testosterone to 5-DHT |
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Finasteride
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(-) both types of 5a-reductase
plasma LH no change |
