Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/5

Click to flip

5 Cards in this Set

  • Front
  • Back
What are the drugs used to treat alzheimer's?
1. ACHE inhibitors
2. NMDA-receptor antagonists
Why are AChE inhibitors used in Alz?
To increase the level of ACh by decreasing its hydrolysis, b/c this is first path to go in the basal forebrain as connect to cortex and hippocampus
What are the AChE inhibitors used in tx of Alz?
Tacrine
Donezepil
**very modest and transient efficacy on behavior and not alter course of dz
Why are NMDA-receptor antag used in ALz?
*Disturbances in the glutamatergic activity play a role in AD-excessive glutamate-mediated activation may lead to neuronal death
What are the NMDA-rec Antag used in AD?
Memantine: low to mod affinity, uncompetitive NMDA-recpetor antag appears to block pathological, but not physiological activation of NMDA receptor.
***Improves sx and reduce rate of clinical deterioration in mod-sev AD