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5 Cards in this Set

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  • Back
What are the drugs used to treat alzheimer's?
1. ACHE inhibitors
2. NMDA-receptor antagonists
Why are AChE inhibitors used in Alz?
To increase the level of ACh by decreasing its hydrolysis, b/c this is first path to go in the basal forebrain as connect to cortex and hippocampus
What are the AChE inhibitors used in tx of Alz?
Tacrine
Donezepil
**very modest and transient efficacy on behavior and not alter course of dz
Why are NMDA-receptor antag used in ALz?
*Disturbances in the glutamatergic activity play a role in AD-excessive glutamate-mediated activation may lead to neuronal death
What are the NMDA-rec Antag used in AD?
Memantine: low to mod affinity, uncompetitive NMDA-recpetor antag appears to block pathological, but not physiological activation of NMDA receptor.
***Improves sx and reduce rate of clinical deterioration in mod-sev AD