Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
What are the drugs used to treat alzheimer's?
|
1. ACHE inhibitors
2. NMDA-receptor antagonists |
|
Why are AChE inhibitors used in Alz?
|
To increase the level of ACh by decreasing its hydrolysis, b/c this is first path to go in the basal forebrain as connect to cortex and hippocampus
|
|
What are the AChE inhibitors used in tx of Alz?
|
Tacrine
Donezepil **very modest and transient efficacy on behavior and not alter course of dz |
|
Why are NMDA-receptor antag used in ALz?
|
*Disturbances in the glutamatergic activity play a role in AD-excessive glutamate-mediated activation may lead to neuronal death
|
|
What are the NMDA-rec Antag used in AD?
|
Memantine: low to mod affinity, uncompetitive NMDA-recpetor antag appears to block pathological, but not physiological activation of NMDA receptor.
***Improves sx and reduce rate of clinical deterioration in mod-sev AD |