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88 Cards in this Set
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* AH 5183 (vesamicol)
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Blocks vesicle packaging
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Decreases ACh vessels
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* botulinum toxin
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Blocks vesicle release
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Decreases ACh in synapse
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* blackwidow spider venom (latrotoxin)
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attacks storage vesicles
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Transient burst of ACh release; then inhibits
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* hemicholinium
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Choline symport uptake block
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Decreases ACh
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* neostigmine
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Reversible AChE inhibitor
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Treat myasthenia gravis; +salivation; bradycardia; +brochial secretions; etc
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* pyridostigmine
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Reversible AChE inhibitor
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Treat myasthenia gravis
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* physostigmine (eserine)
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Reversible AChE inhibitor
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Antidote to atropine(+ACh in synapse; overcomes atropine); treat glaucoma
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* edrophonium
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Reversible AChE inhibitor
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Dx of myasthenia gravis; Short Acting
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* echothiophate
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Irreversible AChE inhibitor
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Treat glaucoma. + charge prevents absorption
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* di-isopropylfluorophosphate; sarin; soman
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Irreversible AChE inhibitor
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Biological warfare
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* parathion
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Irreversible AChE inhibitor
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Insectiside: bronchoconstriction; +airway secretions; bradycardia; etc.
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* chlorpyrifos
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Irreversible AChE inhibitor
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Insectiside: bronchoconstriction; +airway secretions; bradycardia; etc.
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* pralidoxime
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AChE Reactivator
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Give quickly after organophosphate poisoning(restore AChE) w/ atropine (to releave symptoms)
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* acetylcholine
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NAChR/MAChR agonist
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activates nicotinic and muscarinic receptors
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* nicotine
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Nicotinic Agonist
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tremors; toxic in children
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* succinylcholine
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Nicotinic Mixed agonist/antagonist Neuromuscular Junction Blocker
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initally activates; but sticks and blocks - Depolarizing. Surgical muscle relax. WARN: action prolonged Pt w/ atypical BChE
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* trimethaphan
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Nicotinic Antagonist: Ganglionic Blocker
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Decrease muscle and neuron excitability ->decrease motility and vascular tone. Used in hypertension emergencies
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* curare
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Nicotinic Anti – Nondepolaring Neuromuscular
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arrow dope; muscle relaxer/paralytic
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Ve;Atra;pancuronium
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Nicotinic Anti – Nondepolaring Neuromuscular
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muscle relaxer/paralytic
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* muscarine
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Muscarinic Agonist
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Poisoning from muschroom. Treat with Atropine. Liver failure
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* pilocarpine
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Muscarinic Agonist
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Decrease intraocular pressure. Glaucoma treatment; cause disphoresis(sweating).
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* bethanecol
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Muscarinic Agonist
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promote voiding/GI motility; +asthma
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* atropine
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Antagonist
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(Blocks post-synaptic ACh receptors ) Red; Hot; Dry; Mad; Blind; Seizing (blocks parasympathetic); dilate pupil; relax = far vision; +HR. Blocks baroreceptors
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* pirenzipine
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Muscarinic1 antagonist
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Atropine analog
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* scopolamine
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Muscarinic Antagonist
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Motion sickness; decrease secretions for surgery
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* carbachol
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NAChR/MAChR agonist
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Glaucoma treatment
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Imatinib mesylate
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BCL/Abl inhibitor
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kinase inhibitor that sits in ATP binding site for BCR/Abl (BCR/Abl prevents apoptosis) Chronic Myelogenous Leukemia
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Erlotinib
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Blocks RTK phosphorylation (EGFR tyrosine kinase inhibitor)
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RTK
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Trastuzumab
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Ab that Blocks RTK receptor
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RTK
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Sorafenib
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Blocks Raf in Ras pathway (inhibits multiple kinases including VEGFR=antiangiogenic)
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RTK
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Sirolimus (rapamycin)
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blocks mTOR of PIP3 pathway
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RTK
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Bevacizimab
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Antiangiogenic
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monoclonal anti-VEFG-Ab
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Gemcitabine
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Antimetabolites
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Only toxic in S phase; non-carcinogenic; similar to dCTP - stops DNA poly
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5-FU
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Antimetabolites
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Only toxic in S phase; non-carcinogenic; similar to dCTP - stops DNA poly
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Methotrexate
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Antimetabolites
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inhibits dihydrofolate reductase
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Cisplatin
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DNA crosslinking
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Pt agent
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Cyclophosphamide
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DNA crosslinking
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mustard gas like cisplatin
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Irinotecan
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Topoisomerase I poison
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topoisomerase I inhibitor.
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Topotecan
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Topoisomerase I poison
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Etoposide
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Topoisomerase II poison
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"Prevents DNA packaging/unpackaging caues Topo II to make ""nicks"" in DNA"
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Teniposide
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Topoisomerase II poison
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"Prevents DNA packaging/unpackaging caues Topo II to make ""nicks"" in DNA"
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Doxorubicin
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Topoisomerase II poison
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stablilize topo II adducts; forms free radicals; intercalation; inhibit helicase
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Daunorubicin
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Topoisomerase II poison
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stablilize topo II adducts; forms free radicals; intercalation; inhibit helicase
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Paclitaxel (taxol)
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Antimitotic
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prevents depoly
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Docetaxel (taxotere)
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Antimitotic
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Vincristine
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Antimitotic
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prevents elongation
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Vinblastine
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Antimitotic
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ether
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First Anesthetic; mild effect on ventilation; cardio; Neg: explosive; N/V; slow induction
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Nitrous Oxide
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Rapid uptake/offset. Minimal card/resp effects. Neg: Low potency; megaloblastic anemia
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halothane
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Inhaled anesthetic; Neg: halothane hepatitis
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isoflurane
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Inhaled anesthetic
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desflurane
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Inhaled anesthetic
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sevoflurane
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Inhaled anesthetic
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dantrolene sodium
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Treatment for malignant hypertension
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Thiopental
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"""Barbituate""
(+) cheap and safe; rapid and pleasent onset (-) slow full recovery hepatic clearance contraindicated in Pt. w/ acute intermittent porphyria" |
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Propofol
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"(-) lipid emulsion can cause pain at injection
(+) most rapid recovery feasible as continuous infusion" |
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Ketamine
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"(-) like PCP - hallucinations
(+) mild resp/cardio effects (-) slow recovery (+) IM injection" |
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* alpha-methyl-paratyrosine (metyrosine)
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TH inhibitor
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Inhibitor of Tyrosine hydroxylase prevents tyrosine -> L-Dopa. Used in pheochromocytoma. (Crystallizes in urine-hematuria)
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* reserpine
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blocks catecholamine packaging
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reduces hypertension (severe depression)
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* guanethidine
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blocks catecholamine packaging/release
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reduces hypertension. Charged. No CNS. Long 1/2; (orthostatic hypotension) (retrograde ejaculation). Requires uptake 1
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* guanadrel
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blocks catecholamine packaging/release
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Like guanethidine but shorter 1/2 life
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* tyramine
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blocks catecholamine uptake 1/+release
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Induce catecholamine release when taken up. Peripheral. Found in pickeled herring; wine
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* cocaine
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blocks catecholamine uptake 1
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inhibitor of catecholamine re-uptake. Especially norepinephrine -> stimulatory
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* imipramine
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Block catecholamineuptake 1
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pargyline
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MAO inhibitor
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treat depression. (Tyramine diets(wine; pickeled herring) ->induce catecholamine release=>hypertensive crisis)
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* deprenyl
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MAO-B inhibitor
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prevents metabolism of Dopamine. Treat Parkinson's
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SSRI anti-depressants
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block serotonin uptake
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keeps more serotonin in synapse - anti-depressant
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* MPTP
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Toxin met. By MAO to MPP+
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Metabolised by MAO to MPP+. Causes Parkinson's
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* carbidopa
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Blocks AAAD
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Prevents conversion of L-Dopa to Dopamine in periphery. Treat Parkinson's (more L-dopa gets to brain)
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* L-dopa
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Converts to dopamine. Treat Parkinson's
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Converts to dopamine. Treat Parkinson's
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* nitecapone
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COMT inhibitor
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Prevents metabolism of Dopamine to 3-methoxytyramine.cytoplasmic. Treat Parkinson's because less L-Dopa->dopamine
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* norepinephrine
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a; B1 agonist
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* epinephrine
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a;b agonist
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* methoxamine
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a1 agonist
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increase BP by causing vasoconstriction
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* phenylephrine
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a1 agonist
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increase BP by causing vasoconstriction
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* clonidine
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a2 agonist
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lower blood pressure
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* alpha-methylnorepinephrine
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a2 agonist
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lower blood pressure
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* isoproterenol
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B agonist
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increase HR/contractility (via B1) and dilate bronchioles (via B2)
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* dobutamine
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B1 agonist
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increase HR/contractility (via B1). Treat CHF
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* albuterol
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B2 agonist
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dilate bronchioles. Treat asthma
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* terbutaline
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B2 agonist
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dilate bronchioles. Treat asthma
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* phenoxybenzamine
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a antagonist; irreversible
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lower blood pressure. Treat patients with pheochromocytoma prior to surgery
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* phentolamine
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a antagonist; reversible
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Used in OR to counteract catecholamine release during surgery
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* prazosin
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a1 antagonist
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antihypertensive (decrease vascular tone)
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* yohimbine
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a2 antagonist
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ED drug
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* propranolol
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B1; B2 antagonist
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Treats cardiac arrhythmias; angina pectoris; hypertension; but blocking B2=broncho constriction (Not for asthmatics)
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* atenolol
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B1 antagonist
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Treat hypertension
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* amphetamines
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block uptake/+release/-MAO
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inhibitor of uptake 1; indrect releasing of vesicular catecholamine; MAO inhitor
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