Pharm Adrenergic Receptors

Front 1

SA node

Back 1

B1 - increase heart rate

Front 2

atria

Back 2

B1 - increase contraction, increase conduction velocity

Front 3

ventricle

Back 3

B1 - increase contraction, increase conduction velocity

Front 4

skin and mucosa arterioles

Back 4

A1 - constrict
B2 - relax (minor)

Front 5

liver and SkM arterioles

Back 5

A1 - constrict (minor)
B2 - relax (predominates)

Front 6

kidney, ab viscera arterioles

Back 6

A1 - constrict
A2 - constrict (in some)
B2 - relax (minor)

Front 7

Coronaries and cerebral blood vessels

Back 7

A1 - constrict (local regulation predominates)
B2 - relax (local regulation predominates)

Front 8

Veins

Back 8

A1 - constrict
A2 - constrict

Front 9

Bronchial SM

Back 9

B2 - relax

Front 10

Intestinal SM nonsphincter

Back 10

A1 - relax
B2 - relax

Front 11

Intestinal SM sphincter

Back 11

A1 - contract

Front 12

Spleen capsule

Back 12

A1 - contract

Front 13

uterus

Back 13

A1 - contract
B2 - relax

Front 14

seminal tract

Back 14

A1 - contract

Front 15

urinary bladder detrusor

Back 15

B2 - relax

Front 16

urinary bladder sphincter and trigone

Back 16

A1 - contract

Front 17

iris (radial muscle)

Back 17

A1 - contract

Front 18

ciliary muscle

Back 18

B2 - relax

Front 19

ciliary epithelial cells

Back 19

B1 - increase aqueous humor

Front 20

Trabecular meshwork

Back 20

B2 - increase outflow of aqueous humor

Front 21

skeletal muscle

Back 21

B2 - increase contractility,
increase K+ uptake, increase glycogenolysis

Front 22

platelets

Back 22

A2 - aggregation

Front 23

mast cells

Back 23

B2 - inhibition of granule release (histamine, leukotriene, 5-HT, etc.)

Front 24

salivary glands

Back 24

A1 - K+ and H2O secretion
B1 - amylase secretion

Front 25

pancrease acini

Back 25

A1 - decrease secretion

Front 26

pancrease beta cells of islets

Back 26

A2 - decreased secretion of insulin

Front 27

pancrease alpha cells of islets

Back 27

B2 - increased secretion of glucagon (slight)

Front 28

kidney

Back 28

B1 - increased renin release

Front 29

liver

Back 29

A1 - glycogenolysis (K+ release)
B2 - glycogenolysis

Front 30

skin pilomotor muscles

Back 30

A1 - contract

Front 31

skin sweat glands

Back 31

A1 - localized secretion

Front 32

fat

Back 32

B3 - lipolysis

Front 33

Sympathetic nerve endings

Back 33

A2 - inhibit NE release

Front 34

Hypothalmus

Back 34

A2 - inhibit activity of efferent sympathetic outflow to peripheral vascular smooth muscle

Front 35

Arterioles -
Predominant Autonomic Tone
Effect of Ganglionic Blockade

Back 35

- Sympathetic
- Vasodilation, hypotension

Front 36

Veins -
Predominant Autonomic Tone
Effect of Ganglionic Blockade

Back 36

- Sympathetic
- Pooling of blood, decreased venous return

Front 37

Heart (atrial muscle and SA node) -
Predominant Autonomic Tone
Effect of Ganglionic Blockade

Back 37

- Parasympathetic
- Tachycardia (generally)

Front 38

Iris -
Predominant Autonomic Tone
Effect of Ganglionic Blockade

Back 38

- Parasympathetic
- Mydriasis

Front 39

Ciliary muscle -
Predominant Autonomic Tone
Effect of Ganglionic Blockade

Back 39

- Parasympathetic
- Cycloplegia

Front 40

GI tract -
Predominant Autonomic Tone
Effect of Ganglionic Blockade

Back 40

- parasympathetic
- Reduced tone and motility

Front 41

Urinary bladder -
Predominant Autonomic Tone
Effect of Ganglionic Blockade

Back 41

- parasympathetic
- Urinary retention

Front 42

Salivary glands -
Predominant Autonomic Tone
Effect of Ganglionic Blockade

Back 42

- parasympathetic
- Dry mouth

Front 43

Sphincter muscle of iris -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 43

Contraction (miosis)

Front 44

Ciliary muscle -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 44

Contraction for near vision

Front 45

GI Motility -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 45

Increase

Front 46

GI sphincters -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 46

Relaxation

Front 47

SA node -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 47

Decrease in rate (negative chronotropy)

Front 48

atria -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 48

- Decrease in contractile strength (negative inotropy)
- decrease in refractory period

Front 49

AV node -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 49

- Decrease in conduction velocity (negative dromotropy)
- increase in refractory period

Front 50

ventricles -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 50

small decrease in contractale strength

Front 51

arteries -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 51

Constriction (high-dose direct effect)

Front 52

veins -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 52

- Dilatation (via EDRF)
- constriction (high-dose direct effect)

Front 53

Bronchial muscles -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 53

Contraction (bronchoconstriction)

Front 54

Bronchial glands -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 54

Stimulation

Front 55

Sweat, salivary, lacrimal, nasopharyngeal glands -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 55

Secretion

Front 56

urinary Detrusor -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 56

Contraction

Front 57

urinary Trigone and sphincter -
Effects of Direct-Acting Parasympathomimetic Stimulants

Back 57

Relaxation