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16 Cards in this Set

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MC drug interaction that kills
Alcohol and any CNS depressant
Drugs that delay gastric emptying
anti-cholinergics
anti-histamines
tri-cyclic antidepressants
Drugs that increase gastric emptying
metoclopramide
laxatives (castor oil)
1. How does tetracycline affect absorption.
2. what foods should it not be given with
1. It has a ring structure that causes chelation in the stomach with ions (eg. Ca, Al, Fe, Mg) and prevents absoprtion.
2. Dairy
Antacids and sucralfate prevent the absorption of...
fluroquinolones
DOC for OD of digoxin and thyroid hormones
cholestyramine (binds bile acids)
Induction of CYP450
barbs
carbamazepine
phenytoin
rifampin
smoking
Inhibition of CYP450
cimetidine
omprazole
erythromycin
grapefruit juice
Tx of barbiturate OD
ion trapping: use bicarb to alkalinize the urine to draw a weakly acidic drug out
Tx of amphetamine OD
ion trapping: Use ammonium CL to acidify the urine to trap weakly basic drugs
what 2 drugs cause increased clotting time
warfarin + aspirin
What does ephedrine do to BP and why
incr b/c it acts as an alpha-stimulant
counteracts effects of anti-hypertensive meds
why are epi and theophylinne used together
tx of asthmatics b/c they have synergistic effect as B-stimulant
harsh NSAID that should be taken with food
indomethacin
phenobarb should not be combined with...b/c it precipitates
cimetidine + amphetamineare weak bases (phenobarb = acid)
drugs that are highly protein bound
1.oral hypoglycemics
2. warfarin
3. phenylbutazone + other NSAIDS
4. phenytoin
5. tolbutamine
6. valproate
7. aspirin