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16 Cards in this Set
- Front
- Back
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MC drug interaction that kills
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Alcohol and any CNS depressant
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Drugs that delay gastric emptying
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anti-cholinergics
anti-histamines tri-cyclic antidepressants |
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Drugs that increase gastric emptying
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metoclopramide
laxatives (castor oil) |
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1. How does tetracycline affect absorption.
2. what foods should it not be given with |
1. It has a ring structure that causes chelation in the stomach with ions (eg. Ca, Al, Fe, Mg) and prevents absoprtion.
2. Dairy |
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Antacids and sucralfate prevent the absorption of...
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fluroquinolones
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DOC for OD of digoxin and thyroid hormones
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cholestyramine (binds bile acids)
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Induction of CYP450
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barbs
carbamazepine phenytoin rifampin smoking |
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Inhibition of CYP450
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cimetidine
omprazole erythromycin grapefruit juice |
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Tx of barbiturate OD
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ion trapping: use bicarb to alkalinize the urine to draw a weakly acidic drug out
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Tx of amphetamine OD
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ion trapping: Use ammonium CL to acidify the urine to trap weakly basic drugs
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what 2 drugs cause increased clotting time
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warfarin + aspirin
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What does ephedrine do to BP and why
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incr b/c it acts as an alpha-stimulant
counteracts effects of anti-hypertensive meds |
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why are epi and theophylinne used together
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tx of asthmatics b/c they have synergistic effect as B-stimulant
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harsh NSAID that should be taken with food
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indomethacin
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phenobarb should not be combined with...b/c it precipitates
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cimetidine + amphetamineare weak bases (phenobarb = acid)
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drugs that are highly protein bound
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1.oral hypoglycemics
2. warfarin 3. phenylbutazone + other NSAIDS 4. phenytoin 5. tolbutamine 6. valproate 7. aspirin |
