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28 Cards in this Set
- Front
- Back
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Tuberus sclerosis
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Boy with MR, facial angiofibromas, seizures, and cardiac rhabdomyomas + astrocytomas
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Beta2 microglobulin (part of MHC Class I) causing problems…
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Polymerizes into beta sheets (amyloid) in the elderly to cause renal and joint Dz
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Diseases associated with SCC (3)
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Xeroderma pigmentosum / albinism (skin), Plummer-Vinson (esophagus), actinic keratosis (skin)
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Epidermal thickening + hyperpigmentation (acanthosis nigricans) is a harbinger of…
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Visceral (lung, stomach, uterus, breast) malignancies
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Ret
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Gain of f(x), implicated in neoplastic processes seen in MEN II/III (aka MEN IIa and IIb)
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Tumor suppressor genes (with associated chromosome and cancer)
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p53 (17p, Li-Fraumeni syndrome), p16 (9p, melanoma), WT1 (11p, Wilm's tumor), NF1 (17q, NF1), NF2 (22q, NF2), DPC/DCC (18q, pancreatic/colon cancer); APC (5q, FAP colon cancer)
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Psammoma body cancers (4)
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PSMM (Papillary thyroid, Serous papillary cystadenocarcinoma, meningioma, malignant mesothelioma)
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Where most brain mets arise from (4)
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Lung, skin, breast, kidney, GI (lung, breast/skin, GI/kidney);
Lots of Bad Stuff Kills Glia |
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Propensity of different cancer locations to spread to liver
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GI > breast > lung; within GI, colon > stomach > pancreas; Cancer Sometimes Penetrates Benign Liver
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Metastasis to bone
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PTT Barnum Loves Kids
Prostate Thyroid Testees Breast Lung Kidney Prostate, Breast >> others |
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Male cancer epidemiology (incidence + mortality)
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Incidence: Prostate (32%), lung, colorectal
Mortality: Lung 33%, prostate (13%) |
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Female cancer epidemiology (incidence + mortality)
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Incidence: Breast (32%), lung, colorectal
Mortality: Lung (23%), breast (18%) |
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Paraneoplastic FX of small cell lung carcinomas (possible FX- each cancer may have different FX) (4)
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Cushing's (ACTH), Hypercalcemia (PTH-rp), SIADH (ADH), Lambert-Eaton MSK weakness (NMJunction antibodies)
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EPO-producing cancers (2)
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RCC, hemangioblastoma (kids neuro tumor)
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Paraneoplastic tumors of CNS
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Intracranial (ADH), EPO (hemangioblastoma)
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Diabetic amyloidosis
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From AE protein (E for endocrine), amylin; DM 2 only
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Amyloidosis associated with medullary thyroid carcinoma
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Calcitonin is overproduced…A-CAL protein
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Selectins and ICAMs in WBC extravasation process
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Both are on the endothelium; selectins mediate rolling (the initial process) by binding WBC SL residues, while ICAMs bind integrins on the WBC for tight binding
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Karyorrhexis vs pyknosis
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DNA fragmentation vs chromatin condensation, respectively
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S-100
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Marker of melanoma, neural tumors
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Bombesin
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Marker of neuroblastoma, lung tumors, gastric tumors
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Ca-125
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General epithelial cancer + ovarian malignancy
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TRAP
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Hairy cell leukemia (B cell)
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Ca-19-9
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Pancreatic adenocarcinoma
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PSA vs PAP
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Prostatic acid phosphatase is for prostate carcinoma; PSA is just a prostate antigen
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Vimentin
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IF filament that is used as a staining marker of connective tissue
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Desmin
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IF filament that is used as a staining marker for muscle
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GFAP
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Glial-associated…used to stain non-neuronal nerve cells (glia)
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