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27 Cards in this Set
- Front
- Back
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amphotericin-B
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polyene
broadest spectrum. given for systemic infections cidal- punches holes in ergosterol lots of side effects- nephrotoxic, fever and chills, rigos, anemia "shake and bake" |
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5-flucytosine (5-FC)
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polyenes
mainly used for cryptococcal meningitis inhibits nucleic acid synthesis causes GI issues, bone marrow issues |
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nystatin
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polyene
cidal- punches holes in ergosterol topical only used for oral flush (Candida) "nasty nystatin" |
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ketoconazole
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triazole
chronic mucocutaneous candida static- inhibits p450 enzymes in ergosterol synthesis |
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miconazole
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topical imidazole
topical fungal infections (cutanious candida) topical only |
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clotimazole
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topical imidazole
topical fungal infections (cutanious candida) topical only |
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fluconazole
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triazole
DOC for cryptococcal meningitis (also used for candida) *does not cover aspergillus or dimorphics except coccidio |
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itraconazole
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triazole
DOC: dermatophytes preferred for dimorphics IV version is at risk for renal impairment |
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voriconazole
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triazole
DOC for aspergillus good for fluconazole-resistant candida antifungal prophylazis in bone marrow pts causes liver enzyme elevation |
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posaconazole
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broad converage
better when taken with meat |
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caspofungin
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echinocandins
inhibits 1,3 D-glucan synthase (inhibits cell wall synthesis) great for candida injections cidal vs candida and yeast static vs. aspergillus and molds |
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micafungin
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echinocandins
inhibits 1,3 D-glucan synthase (inhibits cell wall synthesis) great for candida injections cidal vs candida and yeast static vs. aspergillus and molds |
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griseofulvin
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old treatment for dermatophytes
inhibits mitosis by disrupting mitotic spindle formation |
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methotrexate
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DMARD
DOC for active RA in non-pregnants inhibits T and B cells and increases adenosine moderate disease |
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sulfasalazine
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DMARD
mild disease DOC fo RA when pregnant prodrug that is converted to sulfapyridine can cause agranulocytosis |
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hydroxychloroquine
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DMARD
mild disease ok for pregnancy slowest acting |
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leflunomide
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DMARD
teratogen arrests cell in G1 phase increases liver enzymes |
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etanercept
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TNF-alpha blocker
BRM monotherapy or combine with methotrexate dont give when there is an infection prevent TNF-a from binding to receptor dont give with preexisiting CHF or demyelination can cause reactivation of TB |
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infliximab
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TNF-alpha blocker
BRM monotherapy or combine with methotrexate dont give when there is an infection prevent TNF-a from binding to receptor dont give with preexisiting CHF or demyelination can cause reactivation of TB |
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adalimumab
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TNF-alpha blocker
BRM monotherapy or combine with methotrexate dont give when there is an infection prevent TNF-a from binding to receptor dont give with preexisiting CHF or demyelination can cause reactivation of TB |
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ankinra
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IL-1 receptor antagonist
BRM dont give with infections |
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abatacept
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BRM
binds B7 on APC (blocks T cell costimulation) dont give with TNF-a blockers |
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rituximab
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BRM
depletes B cells dont give when there are infections |
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colchicine
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acute gout attack
anti-inflammatory (prevents microtubule polymerization) causes diarrhea and vomitting |
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probencid
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chronic gout (underexcretion)
decreases uric acid reabsorbtion in kidney can cause kidney stones when given acutely |
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sulfinpyrazone
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chronic gout (underexcretion)
decreases uric acid reabsorbtion in kidney can cause kidney stones when given acutely |
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allopurinol
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chronic gout (overproducers)
xanthine oxidase inhibitor |
