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29 Cards in this Set

  • Front
  • Back
acute abd colic and CNS changes (including acute encephalopathy in children) is a sign of what type of poisoning?
acute lead poisoning
characteristic sign of chronic lead poisoning?
wrist drop
(peripheral neuropathy)
periph neuropathy, anorexia, anemia, tremor, wt loss and GI sxs are signs of what type of poisoning?
chronic lead poisoning
DOC for lead poisoning?
EDTA +/- dimercaprol
DOC for child that presents with growth retardation, neurocognitive deficits, and developmental delay?
succimer
(chronic lead poisoning)
Px with what is contraindicated in workers exposed to lead?

what should be used?
chelating agents (lead abs may be enhanced)

high dietary Ca (impedes lead abs)
rare poisoning characterized by hallucinations, HA, irritability, convulsions and coma?
organic lead (tetraethyl or tetramethyl lead from leaded gasolines)
DOC for poisoning characterized by severe GI pain, vomiting, secretory diarrhea, capillary damage w/ dehydration and shock;
may have sweet, garlicky odor to breath and stools
Dimercaprol (acute arsenic)
sxs of chronic arsenic poisoning?
skin chgs, hair loss, BMS, anemia, chronic nausea and GI disturbances
massive hemolysis in a man that works with semiconductors
arsine gas
inhalation of what causes CP, SOB, N/V, kidney damage, gastroenteritis and CNS damage?

tx?
inorganic elemental mercury

oral succimer or IM dimercaprol
sxs following ingestion of mercuric chloride?
severe hemorrhagic gastroenteritis and renal failure
what should NOT be used in a pt with gingivitis, discolored gums, loose teeth, and tremor of fingers and arms?
(chronic mercury poisoning)

do NOT use dimercaprol
(may redistribute it to the CNS)
type of poisoning occurring downstream from vinyl plastics factory or consumption of grain intended to be seed and thus treated with heavy metal fungicide?
organic mercury poisoning
MCC acute iron poisoning?
ingestion of ferrous sulfate tablets in small children
poisoning characterized by vomiting, GI bleeding, lethargy, gray cyanosis, poss followed by sev GI necrosis, pneumonitis, jaundice, seizures, coma?
Iron
DOC for iron poisoning?
deferoxamine
oily liquid given parenterally with EDTA for lead poisoning, and alone for acute arsenic and mercury poisoning?
dimercaprol
after drug tx for an acute poisoning, pt develops HTN, tachycardia, HA, N/V, paresthesias and fever. What was drug?
dimercaprol
sxs associated with long term use of dimercaprol
TCpenia, elevated PT
water-soluble chelators similar to dimercaprol?
succimer, unithiol
what sxs may follow tx with the DOC for copper poisoning or Wilson's disease?
nephrotox w/ proteinuria, pancytopenia, autoimmune dysfxn (SLE-like syndrome, hemolytic anemia)
for tx of lead poisoning, a special salt of EDTA is typically used for what reason?
it chelates Ca and may lead to hypocalcemia
most important adverse effect of EDTA tx?

avoid by doing what?
nephrotox, i.e. renal tubular necrosis

adequate hydration and restrict tx to 5 days or less
DOC to treat the complications of tx for thalassemia?
deferoxamine

(transfusions -> iron overload)
toxicity of deferoxamine?
skin rxns (blushing, erythema, urticaria);
long-term use: retinal degeneration, hepatic and renal dysfxn, severe coagulopathies
cause of possible hypotensive shock following deferoxamine tx?
histamine release from rapid IV infusion
"milk and roses" complexion, GI distress, hyperpigmentation and white lines on nails are characteristic of poisoning with what?
arsenic
heavy metal most likely to cause decrease in heme biosynthesis?
inorganic lead