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29 Cards in this Set
- Front
- Back
acute abd colic and CNS changes (including acute encephalopathy in children) is a sign of what type of poisoning?
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acute lead poisoning
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characteristic sign of chronic lead poisoning?
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wrist drop
(peripheral neuropathy) |
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periph neuropathy, anorexia, anemia, tremor, wt loss and GI sxs are signs of what type of poisoning?
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chronic lead poisoning
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DOC for lead poisoning?
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EDTA +/- dimercaprol
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DOC for child that presents with growth retardation, neurocognitive deficits, and developmental delay?
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succimer
(chronic lead poisoning) |
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Px with what is contraindicated in workers exposed to lead?
what should be used? |
chelating agents (lead abs may be enhanced)
high dietary Ca (impedes lead abs) |
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rare poisoning characterized by hallucinations, HA, irritability, convulsions and coma?
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organic lead (tetraethyl or tetramethyl lead from leaded gasolines)
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DOC for poisoning characterized by severe GI pain, vomiting, secretory diarrhea, capillary damage w/ dehydration and shock;
may have sweet, garlicky odor to breath and stools |
Dimercaprol (acute arsenic)
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sxs of chronic arsenic poisoning?
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skin chgs, hair loss, BMS, anemia, chronic nausea and GI disturbances
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massive hemolysis in a man that works with semiconductors
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arsine gas
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inhalation of what causes CP, SOB, N/V, kidney damage, gastroenteritis and CNS damage?
tx? |
inorganic elemental mercury
oral succimer or IM dimercaprol |
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sxs following ingestion of mercuric chloride?
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severe hemorrhagic gastroenteritis and renal failure
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what should NOT be used in a pt with gingivitis, discolored gums, loose teeth, and tremor of fingers and arms?
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(chronic mercury poisoning)
do NOT use dimercaprol (may redistribute it to the CNS) |
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type of poisoning occurring downstream from vinyl plastics factory or consumption of grain intended to be seed and thus treated with heavy metal fungicide?
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organic mercury poisoning
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MCC acute iron poisoning?
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ingestion of ferrous sulfate tablets in small children
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poisoning characterized by vomiting, GI bleeding, lethargy, gray cyanosis, poss followed by sev GI necrosis, pneumonitis, jaundice, seizures, coma?
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Iron
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DOC for iron poisoning?
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deferoxamine
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oily liquid given parenterally with EDTA for lead poisoning, and alone for acute arsenic and mercury poisoning?
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dimercaprol
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after drug tx for an acute poisoning, pt develops HTN, tachycardia, HA, N/V, paresthesias and fever. What was drug?
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dimercaprol
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sxs associated with long term use of dimercaprol
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TCpenia, elevated PT
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water-soluble chelators similar to dimercaprol?
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succimer, unithiol
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what sxs may follow tx with the DOC for copper poisoning or Wilson's disease?
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nephrotox w/ proteinuria, pancytopenia, autoimmune dysfxn (SLE-like syndrome, hemolytic anemia)
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for tx of lead poisoning, a special salt of EDTA is typically used for what reason?
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it chelates Ca and may lead to hypocalcemia
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most important adverse effect of EDTA tx?
avoid by doing what? |
nephrotox, i.e. renal tubular necrosis
adequate hydration and restrict tx to 5 days or less |
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DOC to treat the complications of tx for thalassemia?
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deferoxamine
(transfusions -> iron overload) |
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toxicity of deferoxamine?
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skin rxns (blushing, erythema, urticaria);
long-term use: retinal degeneration, hepatic and renal dysfxn, severe coagulopathies |
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cause of possible hypotensive shock following deferoxamine tx?
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histamine release from rapid IV infusion
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"milk and roses" complexion, GI distress, hyperpigmentation and white lines on nails are characteristic of poisoning with what?
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arsenic
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heavy metal most likely to cause decrease in heme biosynthesis?
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inorganic lead
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