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32 Cards in this Set
- Front
- Back
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Short acting insulin drugs |
Lispro, aspart, glulisine |
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Short acting insulin drugs |
regular insulin |
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intermediate acting insulin drugs |
NPH |
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Long acting insulin drugs |
Glarging, detemir |
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Receptor type for insulin |
tyrosine kinase |
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Insulin effect on liver |
increased glucose stored as glycogen |
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Insulin effect on muscle |
increased glycogen and protein synthesis, increased K uptake |
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Insulin effect on fat |
Increased TG storage |
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Clinical uses of Insulin |
Type 1/2 and gestational DM, hyperkalemia, and hyperglycemia |
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MOA of metformin |
biguanides increase sensitvity to insulin decreasing gluconeogen, increasing glycolysis, and increasing peripheral glucose uptake (increased uptake) |
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First line therapy of DM? |
Metformin |
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Most serious side effect of metformin? |
lactic acidosis |
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metformin is CI in which patients? |
renal failure |
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First generation sulfonylurea |
tolbutamide, chlorpropamide |
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Second generation sulfonylurea |
glyburide, glimepiride, glipizide |
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MOA of sulfonylureas |
close K channels in Beta cell membrane--> depolarizes --> insulin release via increased Ca influx (insulin release increased) |
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Sulfonylurea uses |
Type 2 DM only |
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Adverse effects of first generation sulfonylureas? |
Disulfiram like effects-when taken with alcohol, |
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Which medications increase insulin sensitivity in peripheral tissues and bind PPAR gamma nuclear transcription regulator? |
Pioglitazone, rosiglitazone |
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Side effects of pioglitazone/ rosiglitazone? |
weight gain, edema, hepatotoxicity, heart failure |
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Which diabetes drugs can cause disulfiram like reactions? |
chlorpropamide, tolbutamide, glypizide |
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Name 2 alpha glucosidase inhibitors |
Acarbose/ miglitol |
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MOA of alpha glucosidase inhibitors |
Inhibits intestinal brush border alpha glucosidases, delays hydrolysis and glucose absorption decreasing postprandial hyperglycemia |
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Adverse effects of alpha glucosidase inhibitors? |
GI disturbances |
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Name an amylin analog |
Pamlintide |
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MOA of pramlintide |
decreases glucagon |
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Uses of pramlintide |
Type 1 and 2 DM |
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Name 2 GLP 1 analogs |
Exenatide, liraglutide |
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MOA of liraglutide |
increase insulin and decrease glucagon |
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Name 5 drugs that increase insulin and decrease glucagon release |
exenatide, liraglutide, linagliptin, saxagliptin, sitagliptin |
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Adverse effect of exenatide/ liraglutide |
nausea, vomiting, pancreatitis |
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Adverse effect of DPP-4 inhibitors |
urinary and respiratory infections |
