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29 Cards in this Set
- Front
- Back
DMPPaction and sites
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nicotinic selective agonist, with predominately adrenal response (sympathetic), raises BP
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ACh action and sites
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agonist of muscarinic and nicotinic receptors, with greater affinity for muscarinic; acts on endothelial cells of vasculature, drops BP
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carbachol action and sites
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same as acetycholine, but not hydrolyzed, so longer acting, allowing for greater expression of nictonic effects, drops BP
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carotid occlusion effects
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reflex activation of SNS and adrenal release of catecholamines, raises BP
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Epi action and sites
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alpha and beta agonist, with greater affinity for beta (=> widening pulse pressure as concentration falls), raises BP
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Histamine action and sites
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H1 and H2 widely distributed, vasodilation, acting on endothelial cells, drops BP
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isoproterenol action and sites
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non-selective beta agonist, drops BP
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McN-A-343 action and sites
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M1agonist, raises BP (initial downswing possibly due to M3 stimulation)
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NE action and sites
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alpha 1 and beta 1 agonist (contrast with non-selective beta response of Epi), raises BP
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Phenylephrine action and sites
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selective alpha agonist, raises BP (long acting)
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pilocarpine action and sites
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muscarinic agonist, similar to ACh and carbachol, lowers BP
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tyramine action and sites
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indirect sympathomimetic amine; increases BP (not active in adrenal system)
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atropine action and sites
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muscarinic antagonist
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vagal stimulation action
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slows/stops heart, drops BP
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bretylium action and sites
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prevents release of catecholamines from sympathetic nerve terminals; does not affect medulla
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botulinus toxin action and sites
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prevents release of ACh at all cholinergic synapses
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chlorpheniramine action and sites
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H1 antagonist (note it reduces but does not block histamine because H2 effect continues unabated)
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cocaine action and sites
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blocks amine uptake pump in sympathetic nerve terminals
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phentolamine action and sites
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blocks alpha adrenergic receptors
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propranolol action and sites
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non-selective beta adrenergic blocker (not good for asthmatics)
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ranitidine action and sites
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H2 antagonist (note it reduces but does not block histamine because H1 effect continutes unabated)
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reserpine action and sites
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depletes catecholamines in PNS and CNS
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trimethaphan action and sites
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antagonist of ganglionic nicotinic receptors
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phenoxybenzamine
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blocks alpha adrenergic receptors
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N-methylatropine
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atropine-like blockade of muscarinic, plus the quaternary nitrogen antagonizes ganglionic nicotinic receptors
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astemizole sites and actions
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antagonizes H1, only partially blocking histamine
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imipramine
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classical amine-uptake blocker
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prazosin sites and effects
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alpha blocker
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labetelol
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alpha and beta blocker
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