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9 Cards in this Set

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  • Back
Buspirone
-Class: 5HT-1A agonist
-Therapeutic Use: anxiolytic (for anxiety)
-Important Side Effects: chest pain, dizziness and headache – possible REM disturbances
-Important Interactions: May increase Haloperidol plasma levels
Sumatriptan:
-Class: 5HT-1B/D Agonist
-Therapeutic Use: used for Acute Migraine attacks (useful in reversing migraines and cluster headaches)
-Important Side Effects: Coronary Vasospasm
-Important Interactions: synergistic interaction w/ Ergots
Tegaserod:
-Class: 5HT-4 partial agonist
-Therapeutic Use: GI prokinetic agent (used in constipation and IBD)
-Important Side Effects: Mild
-Important Interactions: Few
Methylsergide:
-Class: 5HT-2 Antagonist
-Therapeutic Use: Migraine Prophylaxis and diarrhea in carcinoid tumors
-Important Side Effects: Peripheral ischemia and chest pain, dizziness and insomnia, nausea
-Important Interactions: Interact w/ beta-blockers to cause peripheral ischemia
Cyproheptadine:
-Class: 5HT-2 selective antagonist
-Indications: Post-gastrectomy dumping syndrome, anti-peristaltic in carcinoid crisis, DOC for uticaria (hives), pruritis, and is also used to counteract sexual dysfunction of SSRI’s such as Fluoxetine.
Ketanserin:
-Class: 5HT-2 antagonist (also an alpha-1 blocker)
-Indicated for HTN and Vasospasm.
-Anti-hypertensive effects may be mediated by blockade of alpha-1 adrenoceptors and/or 5HT-2 Rc on smooth muscle
Clozapine:
-Class: 5HT-2 Antagonist (and DA antagonist)
-Therapeutic Use: Tx of Psychosis (anti-psychotic, treats the negative symptoms of Schizophrenia)
-Important Side Effects: Agranulocytosis
-Important Interactions: Additive effects w/ anti-cholinergics and potentiation of hypotensive effects.
Ondansetron:
-Class: 5HT-3 Antagonist (blocks 5HT-3 Rcs in CTZ (area postrema) and vagal afferents in GI)
-Therapeutic Use: Tx of nausea and vomiting (chemotherapy induced)
-Important Side Effects: headaches
-Important Interactions: metabolized by P450, may be effected by Cimetadine or Phenobarbital.
Granisetron
-Class: 5HT-3 Antagonist (blocks 5HT-3 Rcs in CTZ (area postrema) and vagal afferents in GI)
-Therapeutic Use: Tx of nausea and vomiting (chemotherapy induced)
-Important Side Effects: headaches
-Important Interactions: metabolized by P450, may be effected by Cimetadine or Phenobarbital.