Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
Buspirone
|
-Class: 5HT-1A agonist
-Therapeutic Use: anxiolytic (for anxiety) -Important Side Effects: chest pain, dizziness and headache – possible REM disturbances -Important Interactions: May increase Haloperidol plasma levels |
|
Sumatriptan:
|
-Class: 5HT-1B/D Agonist
-Therapeutic Use: used for Acute Migraine attacks (useful in reversing migraines and cluster headaches) -Important Side Effects: Coronary Vasospasm -Important Interactions: synergistic interaction w/ Ergots |
|
Tegaserod:
|
-Class: 5HT-4 partial agonist
-Therapeutic Use: GI prokinetic agent (used in constipation and IBD) -Important Side Effects: Mild -Important Interactions: Few |
|
Methylsergide:
|
-Class: 5HT-2 Antagonist
-Therapeutic Use: Migraine Prophylaxis and diarrhea in carcinoid tumors -Important Side Effects: Peripheral ischemia and chest pain, dizziness and insomnia, nausea -Important Interactions: Interact w/ beta-blockers to cause peripheral ischemia |
|
Cyproheptadine:
|
-Class: 5HT-2 selective antagonist
-Indications: Post-gastrectomy dumping syndrome, anti-peristaltic in carcinoid crisis, DOC for uticaria (hives), pruritis, and is also used to counteract sexual dysfunction of SSRI’s such as Fluoxetine. |
|
Ketanserin:
|
-Class: 5HT-2 antagonist (also an alpha-1 blocker)
-Indicated for HTN and Vasospasm. -Anti-hypertensive effects may be mediated by blockade of alpha-1 adrenoceptors and/or 5HT-2 Rc on smooth muscle |
|
Clozapine:
|
-Class: 5HT-2 Antagonist (and DA antagonist)
-Therapeutic Use: Tx of Psychosis (anti-psychotic, treats the negative symptoms of Schizophrenia) -Important Side Effects: Agranulocytosis -Important Interactions: Additive effects w/ anti-cholinergics and potentiation of hypotensive effects. |
|
Ondansetron:
|
-Class: 5HT-3 Antagonist (blocks 5HT-3 Rcs in CTZ (area postrema) and vagal afferents in GI)
-Therapeutic Use: Tx of nausea and vomiting (chemotherapy induced) -Important Side Effects: headaches -Important Interactions: metabolized by P450, may be effected by Cimetadine or Phenobarbital. |
|
Granisetron
|
-Class: 5HT-3 Antagonist (blocks 5HT-3 Rcs in CTZ (area postrema) and vagal afferents in GI)
-Therapeutic Use: Tx of nausea and vomiting (chemotherapy induced) -Important Side Effects: headaches -Important Interactions: metabolized by P450, may be effected by Cimetadine or Phenobarbital. |