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8 Cards in this Set

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Ergonovine
Amine
-Class: agonist at alpha-1 and 5HT-2 Receptors
-Therapeutic Use: Postpartum bleeding and labor induction when oxytocin-resistant
-Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction
-Important Interactions: Contraindicated in CV disease and pyschosis
Methylergonovine
Amine
-Class: agonist at alpha-1 and 5HT-2 Receptors
-Therapeutic Use: Postpartum bleeding and labor induction when oxytocin-resistant
-Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction
-Important Interactions: Contraindicated in CV disease and pyschosis
Dihydroergotamine:
Amino Acid
-Class: Ergot Alkaloid (5HT agonist) Non-selective
-Therapeutic Use: Moderate to severe migraine
-Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction
-Important Interactions: Contraindicated in CV disease and pyschosis
Ergotamine:
Amino Acid
-Class: Ergot Alkaloid (5HT agonist) Non-selective
-Therapeutic Use: Moderate to severe migraine
-Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction
-Important Interactions: Contraindicated in CV disease and pyschosis
Ergotamine Tartrate:
Amino Acid
-Class: Ergot Alkaloid (5HT agonist) Non-selective
-Therapeutic Use: Moderate to severe migraine
-Important Side Effects: ergotism (vasoconstriction) leading to gangrene and bowel infarction
-Important Interactions: Contraindicated in CV disease and pyschosis
Bromocriptine: (first ergot that was truly DA selective)
Amino Acid
-Used in Hyperprolactinemia (DA inhibits prolactin secretion), Parkinsons, and Acromegaly
-This is a DA D2 Rc Agonist, so it inhibits prolactin secretion, replaces lost DA in Parkinson’s patient, and lowers blood levels of growth hormone in patients w/ acromegaly.
Pergolide:
Atypical
-Similar to Bromocriptine, selective for D2 and Serotonin, but 1000x more potent than Bromocriptine.
-Indicated for adjunct treatment of levodopa/carbidopa in management of Parkinson’s
-DA Rcs agonist at D1 and D2 Rcs, stimulates DA Rcs in Nigrostriatal System
Cabergoline
Atypical
-Indicated for hyperprolactinemia disorders
-Agonist at DA D2 Rcs, more selective than Bromocriptine and Pergolide.