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28 Cards in this Set
- Front
- Back
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Chronic psychotic disorder involving impaired behavior and disturbances of thinking and effect
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Schizophrenia
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Used to treat schizophrenia and other psychoses
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Phenothiazines
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What do many phenothiazines have in common?
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The ability to block dopamine (DA) receptors in the CNS
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What is thought to contribute to:
1. Therapeutic Actions 2. Extrapyramidal Tract (EPT) side effects 3. Elevated prolactin levels 4. Antiemetic effects |
DA receptors antagonism
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Areas which coordinates muscle movement is known as
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Extrapyramidal Tract (EPT)
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This is due to a decrease in DA/ACh ratio
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Parkinsons Disease
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What is ironic about many antipsychotic drugs?
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They reduce the ration producing side effects similar to parkinsons disease
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Besides the effects similar to parkinsons, what other effects to antipsychotic drugs have (4 more)
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Anticholinergic
Antiadrenergic Sedation Photosensitivity |
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What is the main classic antipsychotic drug that was first available and still referred to as a major tranquilizer?
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Chloropromazine ((thorazine) prototype
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What are some long term concerns for Atypical antipsychotics?
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Hypergylcemia and hypercholesterolemia
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What Atypical drug at higher does resemble older phenothiazines?
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Risperidone
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What atypical drug has a lower risk of EPT effects than b and may also be effective short term for mania
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Olanzapine (Zyprexa)
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What are the concerns of physical therapy and exercise for antipsychotic drugs
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Thermoregulation and UV exposure problems
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Depression is caused by what antihypertensive that deplete NE and %HT in the CNS?
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Reserpine
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This is due to a decrease in 5HT and NE activity in CNS
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Depression
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About what percent of the population experiences depression in their lifetime?
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10%
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What are the Four antidepressant drug Classifications
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1. Tricyclic antidepressants
2. 2nd and 3rd generations "atypical" drugs 3. SELECTIVE serotonin reuptake inhibitors (SSRI) 4. Monoamine oxidase (MAO) inhibitors |
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Which of the antidepressant drugs inhibits the reputake of NE and 5 HT allowing them to accumulate in the synapse and tigger long-term changes. 2-3 weeks
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Tricyclic antidepressants
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Many of the drugs in the tricyclic antidepressants are converted to what?
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metabolites
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Bupropion (Wellbutirn) and Venlafaxine (effexor) are part of which classification of antidepressant drug?
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2nd and 3rd generation (Atypical) drugs
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Which 2nd and 3rd generation atypical drug exhibits:
1. No effect on NE or 5 HT reuptake 2. Amphetamine-like effects(anxiety, restlessness, insomnia) 3. no sexual dysfunction 4. may improve smoking abstinence |
Bupropion (wellbutrin)
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Which 2nd and 3rd generation atypical drug exhibits:
1. Metabolized to an active metabolite 2. inhibits reputake of both NE and 5 HT |
Venlafaxine
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Fluoxetine (Prozac) /desmethylfluoxetine (active metabolite) are prototypes for which drug classification
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Selective serotonin reuptake inhibitors (SSRI)
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What are the advantages of SSRIs over TCA?
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1. Usually have a higher TI
2. Most are tolerated better 3. Effective for some anxiety disorders |
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What are some disadvantages for SSRIs
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1. Sexual Dysfunction
2. P450 inhibition 3. Suicidal behavior 4. Pregnancy 5. Seratonin syntrome |
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Phenelzine (nardil) and tranylcypromin (Parnate) are examples of which Anti-depressant classification?
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MAO inhibitors
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Many time MAOIs produce what type of effect?
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Irriversible effect for a prolonged duration of action
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What is reserved for depression unresponsive to other drugs?
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MAOI
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