Pharm-5 Ab: Moa: Cell Wall Synthesis Inhibitors

Front 1

Penicillin G & V

Back 1

Inhibit transpeptidation rxn cross-linking adj peptidoglycan strands (bactericidal)

Front 2

Methicillin

Back 2

Inhibit transpeptidation rxn cross-linking adj peptidoglycan strands, side chain prevents B-lactamase action (penicillinase resistant penicillins) (bactericidal)

Front 3

oxacillcin

Back 3

Inhibit transpeptidation rxn cross-linking adj peptidoglycan strands, side chain prevents B-lactamase action (penicillinase resistant penicillins) (bactericidal)

Front 4

dicloxacillin

Back 4

Inhibit transpeptidation rxn cross-linking adj peptidoglycan strands, side chain prevents B-lactamase action (penicillinase resistant penicillins) (bactericidal)

Front 5

naficillin

Back 5

Inhibit transpeptidation rxn cross-linking adj peptidoglycan strands, side chain prevents B-lactamase action (penicillinase resistant penicillins) (bactericidal)

Front 6

ampicillin

Back 6

Inhibit transpeptidation rxn cross-linking adj peptidoglycan strands, side chain increases spectrum (aminopenicillin) (bactericidal)

Front 7

amoxicillin

Back 7

Inhibit transpeptidation rxn cross-linking adj peptidoglycan strands, side chain increases spectrum (aminopenicillin) (bactericidal)

Front 8

piperacillin

Back 8

Inhibit transpeptidation rxn cross-linking adj peptidoglycan strands, side chain increases spectrum (extended spectrum penicillin) (bactericidal)

Front 9

unasyn

Back 9

suicide inhibition of penicillinase allows penicillins to be effective (penicillinase inhibitors w/ penicillins) (bactericidal)

Front 10

zosyn

Back 10

suicide inhibition of penicillinase allows penicillins to be effective (penicillinase inhibitors w/ penicillins) (bactericidal)

Front 11

augmentin

Back 11

suicide inhibition of penicillinase allows penicillins to be effective (penicillinase inhibitors w/ penicillins) (bactericidal)

Front 12

Fosfomycin

Back 12

binds and inactivate phosphoenol pyruvate halting muramic acid synthesis (bactericidal)

Front 13

bacitracin

Back 13

combines with carrier molecules, preventing cell wall synthesis (bactericidal)

Front 14

1st gen Cephalosporins

Back 14

inhibits transpeptidation rxn, does not penetrate CNS (bactericidal)

Front 15

2nd gen Cephalosporins

Back 15

inhibits transpeptidation rxn (bactericidal)

Front 16

3rd gen Cephalosporin

Back 16

inhibits transpeptidation rxn, does penetrate CNS (bactericidal)

Front 17

carbapenems

Back 17

inhibits transpeptidation rxn, must be coupled to enzyme inhibitor (cilastin) to prevent rapid metabolism by kidney dipeptidase (bactericidal)

Front 18

monobactams

Back 18

inhibit transpeptidation rxn (bactericidal)

Front 19

vancomycin

Back 19

binds rapidly and irreversible to D-alanyl-D-alanine on peptide side chain -> inhibition of chain extension and transpeptidation (bactericidal)

Front 20

daptomycin

Back 20

pore formation in cell wall and disrupt peptidoglycan synthesis (bactericidal)

Front 21

echinocandins

Back 21

inhibit biosynthetic enzymes that form fungal cell wall

Front 22

maraviroc

Back 22

combines with substrate of Cell Wall (CCR5 receptor) preventing fusion

Front 23

isoniazid

Back 23

competes with pyridoxine, inhibits the enzyme, prevents mycolic acid synthesis (anti-TB)