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38 Cards in this Set

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Define
Parmacokinetics
Changes of plasma concentration & amount of drug in the body after taking.
Define
Excretion
Elimination of a medication from the body.
Define
Distribution
Process of a drug leaving the blood stream & entering the cells or tissues.
Define
Metabolism
Process of the body chemically altering drugs through enzymatic action.
Define
Bioavailability
The fraction of a drug that reaches the systemic circulation.
Define
Absorption
Transfer of a drug to the blood stream.
Define
Pharmacology
Science of drugs & everything about them.
Define
Pharmacodynamics
Study of uptake movement, binding & interactions of drugs at their tissue sites of action. (molecule level)
Define
Half-life (t1/2)
Time required for the concentration of a drug to drop by 50%.
Define
Steady state
Plasma concentration of a drug remains constant.
(rate of elimination = rate of input)
Define
Efficacy
Maximium response produced by a drug.
Define
Potency
How much of a drug is needed to get a given response.
(increase potency = decrease dose)
Define
Agonist
Agent that can bind to a receptor & get a response.
Define
Partial-agonist
Agent that blocks the binding site & causes less response.
Define
Antagonist
Blocks the action of agonist by interacting w/a receptor.
Define
Therapeutic index
Ratio of toxic dose to effective dose.
(TI=Toxic dose/effective dose)
Define
Volume of distribution (Vd)
Hopothetical volume
Relationship between total amount of drug in the body & concentration in the blood.
what is the superscription?
Contains Rx symbol
(means take thou or recipe)
What are the 4 magor parts of a prescription?
Superscription
Inscription
Signature or Sig
Subscription
What is the inscription?
Specifies the name & strength of the drug.
What is the Signature (Sig)?
Directions & route.
What is the Subscription?
# of doses, quantity, form of the drug.
FDA Pregnancy Category A
No risk to the fetus.
(studies were done on pregnant women)
FDA Pregnancy Category B
No evidence of risk in humans.
(if human studies were not done there was no risk found in animal studies)
FDA Pregnancy Category C
Risk cannot be ruled out.
(studies lacking)
Potential benefits may justify the risks.
FDA Pregnancy Category D
Evidence of risk.
Potential benefits may outweigh the risks (life threatened)
FDA Pregnancy Category X
Contraindicated in pregnancy. (fetal risk definatley outweighs any benefit)
Schedule I
Highly abused, illegal.
Schedule II
High abuse potential.
Multiple copy
No phone in (except emergancy)
Pt must see practioner for refill.
Schedule III
Rx good 6mos
5 refills
Phone in OK
Schedule V
Low potential for abuse.
Rx good for 6 mos
5 refills OK
Phone OK
Noncontrolled
No abuse potential
Rx good for 1 year
Unlimited refills
Phone OK
Benefits of medication administered by inhalation;
Large surface area & blood flow gives quick onset.
(reduces sestemic SE)
Benefits of medication administered by intranasal;
Large amount of capillaries = rapid onset.
Benefits of medication administered
Intrathecal/Intraventricular;
Direct to CSF
Benefits of medication administered Topical;
Local effect
(acne, antifungals)
Benefits of medication administered
Transdermal;
Controlled release.
Define
Antagonist
Blocks the drug from getting to the site.