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16 Cards in this Set
- Front
- Back
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OH rings on SPMs
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absence of one or both greatly increases oral effectiveness
- absence of both lets it cross BBB |
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alpha-carbon on SMPs
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enhances resistance to MAO and increases oral effectiveness and duration
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treating a SPM overdose
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acidificaion of urine will protinate SPMs, which are usually weak bases
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phenylephrine
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- A agonist
- decongestion of MMs - hypotension - paroxysmal atrial tachycardia - mydriasis |
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epinephrine
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- A1 and B2 agonist
- vasoconstriction for local anesthesia - control of hemorrhage - hemostasis during surgery - main drug for TIHR, esp w/ cardiac arrest and glaucoma |
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ephedrine
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- A agonist
- hypotension - stress incontinence |
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albuterol
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- B2-receptor selective agonist
- used to treat asthma b/c it relaxes bronchial SM |
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salmeterol
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- B2-receptor selective agonist
- used to treat asthma b/c it relaxes bronchial SM |
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isoproterenol
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- B-receptor selective agonist
- used to treat asthma b/c it relaxes bronchial SM |
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isoproterenol trade names
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Isuprel
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acute anaphylactic Type I hypersensitivity reactions
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- antigens (bee venom, penicillin) evoke production of IgE that fixes to mast cells -> whole cascade
- vasodilation, vaso perm, edema, SM contration or relaxation can lead to death |
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EPI in TIHR
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- B2 receptor activation on mast cells increases cAMP levels and prevents degranulation
- A1 receptor activation supports blood pressure and prevents suffocation |
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dobutamine
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- acute heart failure in TIHR
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Dopamine use
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circulatory shock
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amphetamine
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- CNS Active Phenylethylamines
- attention deficit hyperactivity disorder |
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dobutamine trade name
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- Dobutrex
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