Pharm 4

Front 1

What is the initial therapy for elderly (>70 y/o), dementia & pts with significant cognitive impairment

Back 1

- Levodopa

Front 2

list the Antipsychotics that can cause PD

Back 2

• Prochloroperazine (Compazine®)
• Chlorpromazine (Thorazine®)
• Trifluoperazine (Stelazine®)
• Thioridazine (Mellaril®)
• Haloperidol (Haldol®)

Front 3

What is the Antiemetics that can cause PD

Back 3

- Metoclopramide (Reglan®)

Front 4

What meds are considered ADJUVANT therapy for PD

Back 4

MOA-B & COMT inhibitors

Front 5

What is the First-line monotherapy for PD for most symptomatic patients; May DELAY need for levodopa for several years

Back 5

Dopamine Agonists

Front 6

List the Dopamine Agonists

Back 6

Non Selective (D1 & D2) Ergot derivatives
--Bromocriptine (Parlodel®)
- D2 Selective Agents / Non - Ergot
Pramipexole (Mirapex®)
Ropinirole(Requip®)
Apomorphine (Apokyn®)
Rotogotine

Front 7

what meds improves rigidity & bradykinesia

Back 7

--stimulation of D2 family
Non Selective (D1 & D2) Ergot derivatives
- D2 Selective Agents / Non - Ergot
Pramipexole (Mirapex®)
Ropinirole(Requip®)
Apomorphine (Apokyn®)
Rotogotine

Front 8

What are the Side effects for Non Selective (D1 & D2) Ergot derivatives

Back 8

Pulmonary fibrosis is a consideration
Postural hypotension, dizziness
Hallucinations, mental confusion
GI disturbances

Front 9

What med is used in recurring hypomotility, “off” episodes (on/off or wearing off)

Back 9

Apomorphine (Apokyn®)

Front 10

What antiemetic is used w/ Apomorphine (Apokyn®)

Back 10

Tigan

Front 11

Major Contraindications for Apomorphine

Back 11

Sulfite sensitivity (preservative)

Front 12

Precursor to dopamine: able to cross BBB & replenish depleted dopamine in brain. Levodopa is also converted into dopamine in periphery

Back 12

Levodopa

Front 13

Dopamine decarboxylase inhibitor: DOES NOT cross BBB.

Back 13

Carbidopa

Front 14

BEST choice for patients with mild to moderate disease reserving immediate release version for when disease is erratic," dec. S/E and dec. weariing off

Back 14

Controlled release preparation
Sinemet
- Ratio of Carbidopa/Levodopa: usually 1:4 or 1:

Front 15

how do u Tx On-Off phenomenon

Back 15

- Change dose--BID - TID
- Controlled release preparation
Sinemet

Front 16

how do u Tx Wearing off effect

Back 16

Apomorphine
-- w/ Tigan

Front 17

What are the drugs that decrease Dopamine catabolism

Back 17

Monoamine Oxidase-B Inhibitors
-Selegiline-w/leve or mono mild
- Rasagiline-IRR/0 insomina/cheese
COMT Inhibitors-never monotherapy
- Entacapone - Peripheral
- Tolcapone - Peripheral & central

Front 18

DOC for drug-induced (anti-psychotics) parkinsonism

Back 18

Anticholinergics
- Benztropine (Cogentin®)
- Trihexyphenidyl (Artane®)

Front 19

what drugs are most effective on tremors and rigidity

Back 19

Anticholinergics
- Benztropine (Cogentin®)
- Trihexyphenidyl (Artane®)

Front 20

list the Anticholinergics

Back 20

- Benztropine (Cogentin®)
- Trihexyphenidyl (Artane®)

Front 21

combination agent containing Carbidopa/levodopa/entacapone

Back 21

• Stalevo®

Front 22

What is the mayor SE of COMT inhibitor

Back 22

discolored urine

Front 23

What is the mayor SE of Tolcapone

Back 23

Hepatotoxic: get LFTs at baseline & on a regular basis

Front 24

What is the Antiviral agent for PD

Back 24

Amantadine

Front 25

livedo reticularis is caused by what drug

Back 25

Amantadine

Front 26

Tx for bradykinesia

Back 26

Amantadine

Front 27

What is the Tx of Hallucinations in PD

Back 27

Stop meds that may contribute to psychosis in order:
Anticholinergics
amantadine
selegiline
dopamine agonists
levodopa/carbidopa

Front 28

What drugs are used to Tx Hallucinations in PD

Back 28

Treat with neuroleptics: use newer agents
- Quetiapine (Seroquel®)
- Olanzapine (Zyprexa®)
- Clozapine (Clozaril®)

Front 29

Identical to Prozac but ONLY indicated for premenstrual dysphoric disorder (PMDD)

Back 29

Sarafem

Front 30

What are the Benzos used to Chronically Tx seizures

Back 30

Clonazepam - absence & myoclonic
Clorazepate - partial

Front 31

treat refractory status epilepticus

Back 31

Midazolam (Versed®):

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